Award Data

DESCRIPTION (provided by applicant): Summary: A laser-based acoustic emission (AE) detection device is proposed for work site structural stability assessment. This new device will take advantage of innovations in laser ultrasonics, artificial intelligence (Al) and advanced acoustic emission technology to provide mine workers with a unique instant, real time stability assessment of immediate rock ...

DESCRIPTION (provided by applicant): The aim of the proposed research is to develop tools for the prediction of the distribution of drug compounds in the human body. There is currently no experimental high throughput screening (HTS) method for determining compound tissue distribution. A drug compound's propensity to be taken up by different tissues and organs affects whether it will reach its acti ...

DESCRIPTION (provided by applicant): The proposed Universal Fingerprinting Chips (UFCs) are microarrays of thousands of oligonucleotide probes designed to interrogate the "sequence space" occupied by essentially any genome or transcriptome. The probe sequences are selected according to specific criteria tailored to the particular application. For example, the probe length will depend on the geneti ...

DESCRIPTION (provided by applicant): Project Summary - A new syndrome-based diagnostic system for rapid detection and identification of category B and C priority pathogens is proposed. Phase 1 will focus on V. cholerae genes and genes from similar pathogens. The technique relies upon a helicase-driven iterative primer extension reaction (HDIE) that uses isothermal, multiplexed target amplification ...

DESCRIPTION (provided by applicant): LED based curing lights are beginning to replace conventional halogen lamps as the first choice for dental photo-curing applications. The target of this proposal is to develop a new generation LED dental curing light. It will be the first curing light that is optimized according to the kinetic response of the dental composite, which plays a key role in determin ...

DESCRIPTION (provided by applicant): Most pharmaceutical synthesis involve condensation or dehydration reactions at some point in the process that generates water as a by-product. This water must be removed since (1) water is often not a desirable component of the finished product, (2) water limits conversion to final product, and (3) water generated slows the reaction rate. Many Pharmaceuticals h ...

DESCRIPTION (provided by applicant): Historically blood oxygenator technology either for short-term by-pass surgery or recently developed long-term strategies has been mass transfer limited by liquid side mass transfer fluid dynamics. Recent active mixing designs have led to systems which remove liquid side fluid limitations and have oxygen and carbon dioxide transport limited by membrane transpo ...

DESCRIPTION (provided by applicant): The objective of this proposed project is to achieve a major transformation in the technology used to assess self-care and social disability in children and youth. Measurement and practical requirements to identify disability and evaluate individual progress across pediatric age-groups and care settings present a serious dilemma to current fixed-item instrument ...

DESCRIPTION (provided by applicant): Alcohol abuse and its medical consequences have a significant negative impact on society, the economy and our health. Currently, however, no clinically available laboratory test can reliably diagnose excessive alcohol use throughout the population or predict the progression of alcohol-induced organ damage. NIAAA has therefore deemed it important to identify mor ...

DESCRIPTION (provided by applicant): Wheelchair users are over twice as likely to be obese as people in the general population. The solution to obesity in the wheelchair user population is the same as it is in the general population, a healthy diet and regular exercise. The limited availability of wheelchair accessible cardiovascular exercise equipment may be contributing to lack of regular exerci ...