Award Data

DESCRIPTION (provided by applicant): Summary: A laser-based acoustic emission (AE) detection device is proposed for work site structural stability assessment. This new device will take advantage of innovations in laser ultrasonics, artificial intelligence (Al) and advanced acoustic emission technology to provide mine workers with a unique instant, real time stability assessment of immediate rock ...

DESCRIPTION (provided by applicant): The aim of the proposed research is to develop tools for the prediction of the distribution of drug compounds in the human body. There is currently no experimental high throughput screening (HTS) method for determining compound tissue distribution. A drug compound's propensity to be taken up by different tissues and organs affects whether it will reach its acti ...

DESCRIPTION (provided by applicant): LED based curing lights are beginning to replace conventional halogen lamps as the first choice for dental photo-curing applications. The target of this proposal is to develop a new generation LED dental curing light. It will be the first curing light that is optimized according to the kinetic response of the dental composite, which plays a key role in determin ...

DESCRIPTION (provided by applicant): The long term goal of this research is to develop and commercialize an Aerodynamic Vectoring Particle Sorter (AVPS) for use as the next generation air sample concentrator for the primary purpose of environmental hazard monitoring. To accomplish this goal, the specific aim of this Phase 1 STTR project is to evaluate the technical and commercial feasibility of ap ...

DESCRIPTION (provided by applicant): The long-term objective of this application is to develop a wearable multi-sensor way finding device for the visually impaired that can function reliably both indoors and outdoors. The Phase I specific aims are to: 1) assemble and test a hardware platform that consists of a pocket-size computer and four sensors: a wireless signal receiver inside a wearable comp ...

DESCRIPTION (provided by applicant): Most pharmaceutical synthesis involve condensation or dehydration reactions at some point in the process that generates water as a by-product. This water must be removed since (1) water is often not a desirable component of the finished product, (2) water limits conversion to final product, and (3) water generated slows the reaction rate. Many Pharmaceuticals h ...

DESCRIPTION (provided by applicant): Historically blood oxygenator technology either for short-term by-pass surgery or recently developed long-term strategies has been mass transfer limited by liquid side mass transfer fluid dynamics. Recent active mixing designs have led to systems which remove liquid side fluid limitations and have oxygen and carbon dioxide transport limited by membrane transpo ...

DESCRIPTION (provided by applicant): The objective of this proposed project is to achieve a major transformation in the technology used to assess self-care and social disability in children and youth. Measurement and practical requirements to identify disability and evaluate individual progress across pediatric age-groups and care settings present a serious dilemma to current fixed-item instrument ...

DESCRIPTION (provided by applicant): Diseases involving the urea cycle are clinically manifest by symptoms diverse as neonatal hyperammonemic coma to postpartum psychosis. Hyperammonemia is the primary phenotype of urea cycle defects but differentiating individual gene deficiencies within the urea cycle involves a complex series of biochemical tests. Products of the following genes are required fo ...

DESCRIPTION (provided by applicant): In 1958, Dr Robert Guthrie was approached by Dr Robert Warner seeking aid to develop a better means to measure phenylalanine in the blood of newborns. Of this interaction was born the bacterial inhibition assay and the beginning of population-based newborn screening for phenylketonuria (PKU). Early identification of affected newborns avoided irreversible brain ...