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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Capsid assembly inhibitors for the treatment of AIDS

    SBC: Achillion Pharmaceuticals, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Current HIV-1 therapy suffers from inadequate viral load suppression due to poor compliance, resistance, and interactions with other drugs and can lead to spread of drug-resistant strains. The current drug cocktails need to include inhibitors of viral components that are likely to slow resistance development. One such target is the HIV-1 capsid, an essential vi ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  2. A Laser-Based Device for Work Site Stability Assessment

    SBC: AAC International            Topic: N/A

    DESCRIPTION (provided by applicant): Summary: A laser-based acoustic emission (AE) detection device is proposed for work site structural stability assessment. This new device will take advantage of innovations in laser ultrasonics, artificial intelligence (Al) and advanced acoustic emission technology to provide mine workers with a unique instant, real time stability assessment of immediate rock ...

    SBIR Phase II 2006 Department of Health and Human ServicesCenters for Disease Control and Prevention
  3. Nebulizing Eculizumab for intrapulmonary C5 inhibition

    SBC: Alexion Pharmaceuticals, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The complement component C5 is common to all three pathways of complement activation. Its involvement in the pathogenesis of asthma is controversial. We have recently shown that the intrapulmonary activation of C5 is critical in animal models of asthma (manuscript, submitted). Our data demonstrated that C5 inhibition has profound effects at all the critical poi ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  4. Salivary Gland System for the Production of Therapeutics

    SBC: American Integrated Biologics, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The overall objective of this proposal is to investigate the feasibility of the ruminant salivary gland as a system for the production of therapeutic human proteins. Protein therapeutics is currently in increased demand for the treatment of disease. Existing production systems have limitations such as low capacity, high cost and lack of appropriate post-tran ...

    SBIR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  5. High-throughput Prediction of Compound Tissue Distribution

    SBC: ANALYTICAL BIOLOGICAL SERVICES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The aim of the proposed research is to develop tools for the prediction of the distribution of drug compounds in the human body. There is currently no experimental high throughput screening (HTS) method for determining compound tissue distribution. A drug compound's propensity to be taken up by different tissues and organs affects whether it will reach its acti ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  6. Computer-Based Training in TSF for Drug Abuse Counselors:Phase II

    SBC: CBT4CBT LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Bridging the gap between science and practice continues as a major problem in the effective delivery of treatments for alcohol abuse and dependence. Twelve Step Facilitation, an empirically supported therapy, is well positioned to bridge this gap. That is, although TSF is a highly structured manual driven approach, its basic tenets are familiar to many counselo ...

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
  7. Computer Based Training for Contingency Management: Phase I

    SBC: CBT4CBT LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Bridging the gap between science and practice remains a significant concern in the effective delivery of treatments for drug abuse. Contingency management (CM) treatments, an empirically supported therapy, is well positioned to bridge this gap. Recent studies demonstrate the efficacy of CM in improving outcomes of substance abusers in community-based clinical s ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  8. TRAINING CLINICIANS TO PERFORM VALIDATED THERAPIES--TSF

    SBC: CBT4CBT LLC            Topic: N/A

    N/A

    SBIR Phase I 1998 Department of Health and Human Services
  9. FIBER OPTIC FLUORESCENCE DETECTOR FOR PHOTOSENSITIZER

    SBC: AURORA OPTICS, INC.            Topic: N/A

    N/A

    SBIR Phase I 1998 Department of Health and Human Services
  10. Development Of A Pulsed Light Emitting Diode Dental Photocuring System

    SBC: B & W TEK INC            Topic: N/A

    DESCRIPTION (provided by applicant): LED based curing lights are beginning to replace conventional halogen lamps as the first choice for dental photo-curing applications. The target of this proposal is to develop a new generation LED dental curing light. It will be the first curing light that is optimized according to the kinetic response of the dental composite, which plays a key role in determin ...

    SBIR Phase II 2006 Department of Health and Human ServicesNational Institutes of Health
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