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Project Summary Abstract Millions of people in the US misuse opioids each yearleading to thousands of deaths and costing billions of dollars in total economic burdenMedication assisted treatmentMATfor opioid use disorderOUDis highly efficaciousbut only a fraction of OUD persons access MATand treatment non adherence is common and associated with poor outcomesThis STTR Fast Track proposal is designe ...

Development Commercialization of a Sensing Device to Detect Vaping Summary The use of e cigarettes or vaping has been steadily increasing since its introductionWhile potentially a tool to wean cigarette smokers from combustible tobaccoone consequence of the introduction of these devices has been the adoption of vaping by adolescentsWhile companies that offer vaping instruments for sale note that t ...

PROJECT SUMMARY ABSTRACTUltrasound isand is poised to remaina ubiquitous biomedical imaging modalityIt is safefasteffectiveand affordableUltrasound imaging innovations are being actively developed to provide inexpensive solutions to public health concerns in areas as diverse as early cancer detectiontargeted drug deliveryand image guided surgeryYet significant barriers to research and innovation i ...

With this phase I submissionIsoPlexis proposes to deliver comprehensive profiling of the immune system as a measure of age dependent health in response to medical challenges or traumaThis assay will connect signaling events in the metabolome and proteome from thousands of single cells in parallel enabling the simultaneous tracking of metabolic activity and protein signaling within each immune cell ...

PROJECT SUMMARY The prevalence of Alzheimer’s Disease (AD) and other dementias is steadily climbing and predicted to affect as many as 16 million Americans by 2050. In 2016, 59% of dementia caregivers reported experiencing high levels of emotional and physical stress, and the risk that the chronic stress of dementia caregiving places on caregivers for developing a range of physical and mental he ...

Project Abstract The opioid epidemic is the U S andapos s most widespread behavioral public health problemwith a higher number of deaths due to drug overdose incompared to deaths due to HIV at the peak of the AIDS epidemicMedication assisted treatmentMATfor opioid use disorderOUDis highly efficaciousHoweveronly a fraction of persons with OUD access MATand treatment non adherence and drop out is co ...

Project SummaryThere is an enormous need for the development of a new class of neurotransmitterNTsensors that are versatileselectivesensitive and reliable to allow investigation of the neurobiological mechanisms of behavior and disease symptomsThis STTR proposal will focus on implementing a novel microarray probe for in vivoreal time sensing of glutamateGLUand gamma aminobutyric acidGABAGLU and GA ...

Executive Summary of Predicate (One Page) Summary of Specific Aims of Phase I Specific Aim 1: Train and evaluate an algorithm to detect pediatric asthma symptoms (cough and wheeze) on a low power, small form factor wearable device. Specifications: 90% sensitivity; false alarm rate: 1 cough episode/day or 1 wheeze episode/day. Evaluate algorithm against medical expert (physician) scoring using the ...

Project Summary Abstract TITLEPERCUTANEOUS TREATMENT OF PERIPHERAL ARTERIAL OCCLUSIVE DISEASE WITH IMPLANTATION OF SERIALBALLOON EXPANDABLEPACLITAXEL ELUTING RESORBABLE SCAFFOLDSthe Efemoral DeviceAbstract Peripheral Arterial Occlusive DiseasePAODalso known as Peripheral Vascular Diseasepoor circulationorhardening of the arteriesis a worldwide plagueSymptomatic PAOD affects approximatelyof the pop ...

ABSTRACT More thanmillion women suffer from pelvic health disordersPHDsin the United Statesa number that is projected to nearly double byThese conditions cost the healthcare system billions annually and negatively affect educational and employment opportunitiesquality of lifeand fertility of patientsWhile studies suggest that PHDs can be managed and improved with educationpractitioners are often c ...