Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Cellular Immunotherapy for SSc

    SBC: CELDARA MEDICAL, LLC            Topic: NIAMS

    Project Summary Systemic sclerosis SSc is a systemic autoimmune disease that results in widespread fibrosis of the skin and internal organs vascular dropout and autoantibody formation SSc has the highest case fatality rate of any systemic autoimmune disease and there remain for FDA approved therapies Analysis of gene expression data on samples collected from SSc patients strongly indicates th ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Flight Head and Hearing Protection System

    SBC: CREARE LLC            Topic: N172120

    Upgrades to the E-2D Advanced Hawkeye inadvertently resulted in higher acoustic loading at its propellers blade pass frequency (BPF). This frequency overlaps with vibrational modes of the standard fixed-wing aircrew helmet, the HGU-68/P. As a combined result, E-2D pilots are experiencing exceptionally large vibrational and acoustic (noise) loading, potentially compromising aircrew performance and ...

    SBIR Phase I 2017 Department of DefenseNavy
  3. High Productivity Low Noise Abrasive Blast Nozzle

    SBC: CREARE LLC            Topic: N172134

    Navy vessels, along with other military, civil, and commercial equipment and structures, are routinely stripped by abrasive blasting in preparation for re-coating. Using existing nozzles, blasting generates continuous noise levels up to 145 dBA, and even with correctly worn double hearing protection, blasting operators are at risk of hearing damage. Noise induced hearing loss has become the most c ...

    SBIR Phase I 2017 Department of DefenseNavy
  4. Novel Inhibitors of PSMB and PSMB for the Treatment of Multiple Myeloma

    SBC: InhiProt            Topic: 103

    Multiple myeloma is incurable hematologic malignancy with an expected median survival of years The proteasome inhibitors bortezomib carfilzomib and the recently approved ixazomib are a mainstay of current myeloma treatment Despite an initial response rate approaching to proteasome inhibitor containing combinations all patients relapse and eventually become resistant to any treatments ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Development of PEGylated MTI for the treatment of relapsed Myeloma

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    ABSTRACT Modulation Therapeutics is developing a first in class cyclic peptide coined MTI for the treatment of multiple myeloma The company currently has a license for the parent molecule which has been awarded a patent covering the intellectual property for both composition of matter and use in cancer in the US and Europe Modulation Therapeutics is now poised to further advance this class ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Robust Predictor of Breast Cancer Risk

    SBC: Morgan and Mendel Genomics, Inc.            Topic: 103

    Summary Approximatelymillion women in the United States are at high risk for developing breast cancerbased on inheritance of a germline mutation in a gene in the double strand breakDSBrepair and cyclin checkpoint pathwaysMany are unaware of their genetic predispositionsbecause their family history is uninformative or unknownGenetic testing is important for identifying mutations in these genesbut i ...

    STTR Phase I 2017 Department of Health and Human Services
  7. Osteopontin targeted therapy for primary CNS lymphoma

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    Abstract Primary central nervous system lymphoma PCNSL is an aggressive brain tumor with a dire unmet therapeutic need It has an overall incidence of per person years and is regarded as an orphan disease with potential for fast track approval Our group made a discovery via gene expression analysis that osteopontin OPN is the most upregulated gene in PCNSL compared to its non CNS ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. STTR Phase I: Rapid Blood Cleansing Device to Combat Infection

    SBC: Path Ex, Inc.            Topic: BM

    The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to develop a dialysis-like platform for selective bacterial separation and removal from blood. This technology could potentially serve as a novel blood cleansing therapy for the treatment of disease, including sepsis. Sepsis, a life threatening organ dysfunction caused by infection, is a co ...

    STTR Phase I 2017 National Science Foundation
  9. SBIR Phase I: Advanced alkaline electrolyzer stack for hydrogen peroxide onsite production

    SBC: Peroxygen Systems, Inc.            Topic: CT

    The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project is a significant advance in the production of hydrogen peroxide. The project, if successful, will yield an on-site electrolytic generation method that reduces the cost of peroxide production by up to 50% compared to the traditional centralized chemical process. By reducing cost, hydrogen peroxide can ...

    SBIR Phase I 2017 National Science Foundation
  10. Complex Dimensional in Vitro Human Skin Tissue Models for Scleroderma

    SBC: CELDARA MEDICAL, LLC            Topic: NIAMS

    Abstract Project Summary Scleroderma Systemic Sclerosis SSc is an autoimmune disease of unknown etiology that is characterized by vascular dysfunction fibrosis and inflammation One in three patients dies within years of diagnosis giving SSc the highest case fatality rate of any systemic autoimmune disease A lack of biologically relevant human SSc disease models has created a critical ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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