Award Data

Current depot-level manufacturing systems are not responsive to changing requirements and flexible specifications. The serial arrangement of individual work cells results in a lengthy timeline to complete the critically-needed part; thus, critical assets

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project will be to enable and support the future development, approval, and clinical use of new therapeutics the cure HIV-1 infection. HIV-1 infection can be controlled by available antiretroviral therapy, but cannot be cured due to the persistence of the virus in a quiescent, or latent state. This l ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project addresses the healthcare needs of the 27 million Americans and 300 million patients globally suffering with type 2 diabetes (T2D). These patients are desperate for a safe treatment that reestablishes glycemic control to augment or replace current management strategies such as metformin and in ...

Summary In recent years opioid use disorder OUD and deaths due to opiate overdose e g with heroin fentanyl oxycodone in suburban and rural non minority groups has created an urgency for approaches to stem this epidemic but the rise in OUD and opiate overdose deaths has occurred in inner cities at similar rates Heroin misuse and addiction are persistent problems in African American commu ...

The broader impact/commercial potential of the Small Business Innovation Research (SBIR) Phase II is to reduce the patient harm and financial burden created by the intensifying problem of emergency department (ED) crowding. ED crowding is a threat to patient safety for high acuity patients and has been associated with avoidable morbidity and mortality across many conditions. Concurrently, EDs are ...

This Small Business Innovation Research (SBIR) Phase II project will develop a resonant light detection and ranging (R-LIDAR) distance sensor based upon use of an optomechanical beam scanning element actuated at resonant frequency. The broader impact of this project is to commercialize distance sensing instrumentation that advances the development of robotic and autonomous systems (RAS) by providi ...

As their first application for veterinary health the two PI s have already remarkably employed their novel patented superagonist and neoglycosylation technology to develop the first recombinant much more potent and long acting bovine FSH antagonists for improved cattle reproduction and a potential $ Million annual market This work was supported by a previous phase SBIR from FDA CVM whic ...

Project Summary Abstractchanges are in Time New Roman fontCutaneous T cell lymphomaCTCLis a rare form of Non Hodgkin s LymphomaNHLaffecting approximatelypatients annually in the United States and can be characterized by either an indolent or aggressive disease progressionEither case is accompanied by significant morbidityparticularly due to the skin effects of the diseaseThe indolent disease may e ...

Project Summary Myologica is a small business focused on developing therapeutics for neuromuscular diseases Started in collaboration with the University of Maryland Myologica maintains a vigorous in house pre clinical discovery program in Duchenne Muscular Dystrophy DMD while providing consultation and specialized neuromuscular function testing for non profit and corporate clients The object ...

Project Summary Systemic sclerosis SSc is a systemic autoimmune disease that results in widespread fibrosis of the skin and internal organs vascular dropout and autoantibody formation SSc has the highest case fatality rate of any systemic autoimmune disease and there remain for FDA approved therapies Analysis of gene expression data on samples collected from SSc patients strongly indicates th ...