Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. A Reconfigurable Machining Center for Depot Productivity Enhancement

    SBC: CREARE LLC            Topic: AF161019

    Current depot-level manufacturing systems are not responsive to changing requirements and flexible specifications. The serial arrangement of individual work cells results in a lengthy timeline to complete the critically-needed part; thus, critical assets

    SBIR Phase II 2017 Department of DefenseAir Force
  2. Cellular Immunotherapy for SSc

    SBC: CELDARA MEDICAL, LLC            Topic: NIAMS

    Project Summary Systemic sclerosis SSc is a systemic autoimmune disease that results in widespread fibrosis of the skin and internal organs vascular dropout and autoantibody formation SSc has the highest case fatality rate of any systemic autoimmune disease and there remain for FDA approved therapies Analysis of gene expression data on samples collected from SSc patients strongly indicates th ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Flight Head and Hearing Protection System

    SBC: CREARE LLC            Topic: N172120

    Upgrades to the E-2D Advanced Hawkeye inadvertently resulted in higher acoustic loading at its propellers blade pass frequency (BPF). This frequency overlaps with vibrational modes of the standard fixed-wing aircrew helmet, the HGU-68/P. As a combined result, E-2D pilots are experiencing exceptionally large vibrational and acoustic (noise) loading, potentially compromising aircrew performance and ...

    SBIR Phase I 2017 Department of DefenseNavy
  4. High Productivity Low Noise Abrasive Blast Nozzle

    SBC: CREARE LLC            Topic: N172134

    Navy vessels, along with other military, civil, and commercial equipment and structures, are routinely stripped by abrasive blasting in preparation for re-coating. Using existing nozzles, blasting generates continuous noise levels up to 145 dBA, and even with correctly worn double hearing protection, blasting operators are at risk of hearing damage. Noise induced hearing loss has become the most c ...

    SBIR Phase I 2017 Department of DefenseNavy
  5. Development of a high-throughput screen to detect the effects of both pre- and post-biotransformed compounds for enhanced content drug discovery workflows

    SBC: 490 BIOTECH INC            Topic: 300

    Development of a high throughput screen to detect the effects of both preand postbiotransformed compounds for enhanced content drug discovery workflows Project Summary This Small Business Innovation Research Phase II project will build upon our successful Phase I demonstration that substrate free autobioluminescent signal generation can detect both the preand post biotransformed metabolic impacts ...

    SBIR Phase II 2017 Department of Health and Human Services
  6. SBIR Phase II: A secure educational interactive software platform for improving high school student achievement

    SBC: BENCHFLY, INC.            Topic: EA

    This SBIR Phase II project is focused on the challenge of significantly improving student achievement in Science, Technology, Engineering, and Math (STEM) concepts through the development of an innovative video software platform that leverages the benefits of video-based active learning in the educational environment. STEM fields are widely regarded as vital to a nation's economy, but a disconnect ...

    SBIR Phase II 2017 National Science Foundation
  7. Novel Inhibitors of PSMB and PSMB for the Treatment of Multiple Myeloma

    SBC: InhiProt            Topic: 103

    Multiple myeloma is incurable hematologic malignancy with an expected median survival of years The proteasome inhibitors bortezomib carfilzomib and the recently approved ixazomib are a mainstay of current myeloma treatment Despite an initial response rate approaching to proteasome inhibitor containing combinations all patients relapse and eventually become resistant to any treatments ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Development of PEGylated MTI for the treatment of relapsed Myeloma

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    ABSTRACT Modulation Therapeutics is developing a first in class cyclic peptide coined MTI for the treatment of multiple myeloma The company currently has a license for the parent molecule which has been awarded a patent covering the intellectual property for both composition of matter and use in cancer in the US and Europe Modulation Therapeutics is now poised to further advance this class ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Enabling point-of-care molecular diagnostics by developing an adaptive PCR instrument and on-demand kit reagents

    SBC: BIOVENTURES, INC            Topic: 172

    Because of its high sensitivitypolymerase chain reactionPCRis the gold standard for the diagnosis of many infectious diseasesbut generally only implemented in well equipped laboratoriesOne of the major roadblocks for expanding PCR to point of care markets is the lack of simplerobustsingle tube PCR designs which preserve its laboratory based high sensitivity and specificityIn this Fast Track STTR a ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  10. A single-cell device to capture and analyze rare T-cells from solid tumors.

    SBC: IsoPlexis            Topic: 102

    Checkpoint inhibitors towards targets such as PDand PD Lare being developed to activate quiescent T cells embedded in tumors and enable them to recruit the rest of the immune system to fight a cancer massHow these new cures reactivate the relatively few Tumor Infiltrating LymphocytesTILsenabling the release of a complex message of cytokines to recruit the immune systemthus impacting treatment effi ...

    SBIR Phase II 2017 Department of Health and Human Services
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