Award Data

Current depot-level manufacturing systems are not responsive to changing requirements and flexible specifications. The serial arrangement of individual work cells results in a lengthy timeline to complete the critically-needed part; thus, critical assets

Project Summary Systemic sclerosis SSc is a systemic autoimmune disease that results in widespread fibrosis of the skin and internal organs vascular dropout and autoantibody formation SSc has the highest case fatality rate of any systemic autoimmune disease and there remain for FDA approved therapies Analysis of gene expression data on samples collected from SSc patients strongly indicates th ...

Upgrades to the E-2D Advanced Hawkeye inadvertently resulted in higher acoustic loading at its propellers blade pass frequency (BPF). This frequency overlaps with vibrational modes of the standard fixed-wing aircrew helmet, the HGU-68/P. As a combined result, E-2D pilots are experiencing exceptionally large vibrational and acoustic (noise) loading, potentially compromising aircrew performance and ...

Navy vessels, along with other military, civil, and commercial equipment and structures, are routinely stripped by abrasive blasting in preparation for re-coating. Using existing nozzles, blasting generates continuous noise levels up to 145 dBA, and even with correctly worn double hearing protection, blasting operators are at risk of hearing damage. Noise induced hearing loss has become the most c ...

Development of a high throughput screen to detect the effects of both preand postbiotransformed compounds for enhanced content drug discovery workflows Project Summary This Small Business Innovation Research Phase II project will build upon our successful Phase I demonstration that substrate free autobioluminescent signal generation can detect both the preand post biotransformed metabolic impacts ...

This SBIR Phase II project is focused on the challenge of significantly improving student achievement in Science, Technology, Engineering, and Math (STEM) concepts through the development of an innovative video software platform that leverages the benefits of video-based active learning in the educational environment. STEM fields are widely regarded as vital to a nation's economy, but a disconnect ...

Multiple myeloma is incurable hematologic malignancy with an expected median survival of years The proteasome inhibitors bortezomib carfilzomib and the recently approved ixazomib are a mainstay of current myeloma treatment Despite an initial response rate approaching to proteasome inhibitor containing combinations all patients relapse and eventually become resistant to any treatments ...

ABSTRACT Modulation Therapeutics is developing a first in class cyclic peptide coined MTI for the treatment of multiple myeloma The company currently has a license for the parent molecule which has been awarded a patent covering the intellectual property for both composition of matter and use in cancer in the US and Europe Modulation Therapeutics is now poised to further advance this class ...

Because of its high sensitivitypolymerase chain reactionPCRis the gold standard for the diagnosis of many infectious diseasesbut generally only implemented in well equipped laboratoriesOne of the major roadblocks for expanding PCR to point of care markets is the lack of simplerobustsingle tube PCR designs which preserve its laboratory based high sensitivity and specificityIn this Fast Track STTR a ...

Summary Approximatelymillion women in the United States are at high risk for developing breast cancerbased on inheritance of a germline mutation in a gene in the double strand breakDSBrepair and cyclin checkpoint pathwaysMany are unaware of their genetic predispositionsbecause their family history is uninformative or unknownGenetic testing is important for identifying mutations in these genesbut i ...