Award Data

Current depot-level manufacturing systems are not responsive to changing requirements and flexible specifications. The serial arrangement of individual work cells results in a lengthy timeline to complete the critically-needed part; thus, critical assets

Development of a high throughput screen to detect the effects of both preand postbiotransformed compounds for enhanced content drug discovery workflows Project Summary This Small Business Innovation Research Phase II project will build upon our successful Phase I demonstration that substrate free autobioluminescent signal generation can detect both the preand post biotransformed metabolic impacts ...

This SBIR Phase II project is focused on the challenge of significantly improving student achievement in Science, Technology, Engineering, and Math (STEM) concepts through the development of an innovative video software platform that leverages the benefits of video-based active learning in the educational environment. STEM fields are widely regarded as vital to a nation's economy, but a disconnect ...

Because of its high sensitivitypolymerase chain reactionPCRis the gold standard for the diagnosis of many infectious diseasesbut generally only implemented in well equipped laboratoriesOne of the major roadblocks for expanding PCR to point of care markets is the lack of simplerobustsingle tube PCR designs which preserve its laboratory based high sensitivity and specificityIn this Fast Track STTR a ...

Checkpoint inhibitors towards targets such as PDand PD Lare being developed to activate quiescent T cells embedded in tumors and enable them to recruit the rest of the immune system to fight a cancer massHow these new cures reactivate the relatively few Tumor Infiltrating LymphocytesTILsenabling the release of a complex message of cytokines to recruit the immune systemthus impacting treatment effi ...

In the Phase I effort, Gloyer-Taylor Laboratories LLC (GTL) verified the feasibility of generating power from space particle radiation. This effort successfully demonstrated electrical power production from a particle radiation source using an initial proof-of-concept device. The effort also identified a second approach that has the potential for even better power generation and offers enhanced ...

This Small Business Technology Transfer Research Phase II will develop and advance the commercialization of STF-ArmorTM nanocomposite materials for use in Environmental Protection Garments (EPG) for extended exploration missions in diverse environments, including LEO, cis-lunar space, and Lunar and Martian surfaces. The Phase II research will optimize and deliver a validated prototype suit compon ...

ImmuNext has identified and developed a putative lead anti VISTA monoclonal antibodymAbthat we aim to bring to the clinic for the treatment of human autoimmune diseaseVISTA is a member of the highly successful negative checkpoint regulatorNCRfamily of drug targetswhose members have demonstrated proven efficacy in inducing long term remissions in human cancersWe contend that antibodies that suppres ...

This proposal responds to RFA–DC-16-002, in which the NIDCD is seeking to support the development of acoustic signal processing tools that have the potential to accelerate research studies and to facilitate the translation of novel algorithms for hearing aids. Approximately 15% of American adults report some degree of hearing trouble, and 12.7% of Americans aged 12 and over experience bilateral ...

Expressing humanized bacterial luciferase in stem cellsMoving beyond firefly luciferase toexpand the informational capacity of animal models for regenerative medicine Project Summary This Small Business Technology TransferSTTRPhase II project proposes to develop complementary autonomously bioluminescentautobioluminescentin vitro stem cell lines and in vivo small animal model systems that enable th ...