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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. A Multimodal Acoustic Tool for Inline Pipe Inspection

    SBC: CREARE LLC            Topic: 180PH1

    A Multimodal Acoustic Tool for Inline Pipe Inspection 3/19/2018 The US energy transport pipeline system is a longstanding distribution network with most of its still standing pipes being installed between the 1950s–1970s. Due to degradation mechanisms, such as embrittlement, capable of causing a two-fold reduction in fracture toughness, pipe rupture is a major risk. Current nondestructive ins ...

    SBIR Phase I 2018 Department of Transportation
  2. Rapid Assessment of Air Void System in Fresh Concrete

    SBC: CREARE LLC            Topic: 171FH2

    Proposal title: Rapid Assessment of Air Void System in Fresh Concrete Water expansion during freeze-thaw cycles can cause deterioration in concrete, leading to scaling, cracking, and crumbling over a period of years. Resistance to this damage is achieved with a system of voids formed by adding surfactants to the fresh concrete to stabilize air bubbles naturally entrained during mixing. The volume ...

    SBIR Phase II 2018 Department of Transportation
  3. GreenCare Interactive Guide for Knee Replacement Surgery

    SBC: PEER Technologies PLLC            Topic: NIA

    Project SummaryAbstract The goal of this Phase I work is to finish development of an innovative interactive app designed to help patients appropriately use total knee replacementTKRsurgery and provide support to achieve best outcomesTKR is highly effective for treating advanced osteoarthritis of the kneebut it has risksAppropriate use can be assured by engaging patients in a Shared Decision Making ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. A High-Throughput, Multi-Omic Assay of Tumor Biomarkers from Single-Cells

    SBC: IsoPlexis            Topic: 172

    SUMMARY Although solid tumors oftentimes arise from the uninhibited growth of a single aberrant cellthe population of cells within a tumor are genetically and molecularly heterogenousThis makes it very difficult to evaluate a therapy s efficacy when using bulk population measurementsFurthermorerecent research has implicated microRNAsmiRNAsas drivers of progression and malignancy in many tumor type ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Targeting leukocyte metabolism to treat human autoimmune disease

    SBC: Immunext, Inc.            Topic: R

    ImmuNext has defined an anti MCTmonoclonal antibodymAbthat will be developed for the treatment of human autoimmune diseaseThe membrane monocarboxylate nutrient transporter SLCAMCTis a multi pass transmembrane protein responsible for the facilitated transport of critical metabolitesincluding products of glycolysislactatepyruvate and ketonesOur strong preliminary data support the tenet that mAbs tha ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Smart Cavity Creator Drill for Lumbar Interbody Fusion

    SBC: PEER Technologies PLLC            Topic: NIBIB

    PROJECT SUMMARYABSTRACT Older patients with persistent and progressive symptoms of chronic back pain and leg pain often have a diagnosis of lumbar degenerative spondyolisthesis and undergo complex lumbar decompression and fusion surgeryOverof these procedures are performed in the United States each yearSurgery is highly effective but technically challengingOne technical challenge of fusion in spon ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Specificity and safety of a targeted therapy against triple negative breast cancer

    SBC: CELDARA MEDICAL, LLC            Topic: 102

    PROJECT SUMMARY ABSTRACT Despite recent advances in the treatment of breast cancerBCthere is a pressing unmet medical need as BC remains the second leading cause of cancer related deaths among womenInnovative new approaches are especially needed to help patients with triple negative BCTNBCas TNBCandapos s inherently aggressive clinical behavior and the lack of recognized molecular targets for ther ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Nanoparticle Probes to Objectively Measure Pain Following Back Surgery

    SBC: PEER Technologies PLLC            Topic: NIDA

    AbstractPost operative pain is poorly managed and increases risk for delayed recoverychronic painopioid dependenceand persistent disabilityOne barrier to effective management of acute pain is the absence of objective measuresWe propose to conduct a feasibility study for technology to objectively measure postoperative painWe have selected back surgery as a model given its frequencycostand poor outc ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Socializing a Science-based Digital Therapeutic for Substance Use Disorders

    SBC: Square2 Systems, Inc.            Topic: NIDA

    Digital therapeutics are redefining the future of medicineDigital therapeutics refer to the use of mobile technology to provide personalizeddigital health interventions to treat diseasesThese tools enable anytime and anywhere healthcareGiven that there are more mobile phones in the world than there are people in the worlddigital therapeutics offer the potential to be transformativeThe applicant te ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. A Smart Sensing Drill to Reduce Incidence of Dental Implant Complications

    SBC: RYTEK MEDICAL, INC.            Topic: NIDCR

    PROJECT SUMMARY ABSTRACT Clinical ImportanceAlmostmillion dental implants were placed worldwide inwithmillion of these procedures taking place in the United StatesThe worldwide market for these implants is expected to increase to $$billion in revenue byas more patients opt for this procedure to regain chewing function and improve cosmetic appearanceThe procedure itself requires an osteotomy be dri ...

    STTR Phase I 2018 Department of Health and Human Services
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