Award Data

WE WILL DEVELOP AN AUTOMATED LOW-TO-MODERATE COST "INTELLIGENT" EVOKED POTENTIAL MONITORING SYSTEM FOR USE IN OPERATING ROOMS AND INTENSIVE CARE UNITS. EVOKED POTENTIAL MONITORING IS DESIRABLE IN OPERATING ROOMS AND INTENSIVE CARE UNITS FOR THE PURPOSE OF RAPID DETECTION OF DELETERIOUS NEUROLOGICAL CHANGES THAT, IF UNRECOGNIZED AND UNCORRECTED, COULD LEAD TO SIGNIFICANT NEUROLOGICAL DEFICITS. AT P ...

CIRCULATORY ASSIST DEVICES ARE NEEDED FOR IMMEDIATE TEMPORARY TREATMENT OF ACUTE MYOCARDIAL INFARCTION AND FOR SOME POSTCARDIOTOMY PATIENTS. IMPLANTED CIRCULATORY ASSIST DEVICES ALSO ARE BEING DEVELOPED FOR LONGER TERM HELP TO AMBULATORY PATIENTS WITH CHRONIC HEART FAILURE. PNEUMATIC AND ELECTROMAGNETICALLY ACTUATED PULSATILE ASSIST DEVICES HAVE BEEN INVESTIGATED, AND IN RECENT YEARS THERE HAS BEE ...

THE GOAL OF THIS PROJECT IS TO DEVELOP AN ARRAY OF 10-(4)CM(2) ELECTRODES FOR USE WITH A NEW INSTRUMENTAL METHOD FOR TISSUE CULTURE. THE METHOD, REFERRED TO AS ECIS (ELECTRIC CELL-SUBSTRATE IMPEDANCE SENSOR), IS A NON-INVASIVE TECHNIQUE TO MEASURE SEVERAL IN VITRO CELL PARAMETERS THAT HAVE PREVIOUSLY BEEN DIFFICULT TO QUANTIFY. THESE INCLUDE CELL MOTILITY, ADHESION AND SPREADING, MORPHOLOGY, AND T ...

THIS RESEARCH WILL DEVELOP A COMPUTER-BASED AID FOR PREVENTIVE HEALTH CARE PLANNING FOR INDIVIDUALS AND FAMILIES PREVAIL (PREVENTIVE HEALTH CARE PLANNING AID FOR FAMILIES) WILL AUTOMATE THE PROCESS OF ASSESSING AN INDIVIDUAL'S MEDICAL, DEMOGRAPHIC AND LIFESTYLE CHARACTERISTICS AND MAPPING THEM ONTO A PERSONALLY TAILORED SET OF PREVENTIVE HEALTH CARE RECOMMENDATIONS. THESE RECOMMENDATIONS WILL BE B ...

THE DISCOVERY OF A COMPETITIVE PHOSPHODIESTERASE (PDE) INHIBITOR WHICH IS SPECIFIC FOR THE LOW KM CALMODULIN (CAM) SENSITIVE FORM OF THE PDE I ISOZYME (CAM- PDE) IS DESIRED. INHIBITION OF CAM-PDE WILL RESULT IN INCREASES OF INTRACELLULAR CYCLIC NUCLEOTIDES, MOST IMPORTANTLY CGMP. IT IS HYPOTHESIZED THAT INHIBITION OF THIS ISOZYME WILL RESULT IN VASCULAR RELAXATION WITHOUT EFFECTS ON INOTROPY AND T ...

CURRENTLY AVAILABLE CLINICIAN-ADMINISTERED DIAGNOSTIC INTERVIEWS TO EVALUATE ALCOHOL, DRUG AND PSYCHIATRIC DISORDERS EITHER ASCERTAIN THESE DISORDERS BY OLDER DIAGNOSTIC CRITERIA, OR ASSESS UP-TO-DATE CRITERIA BUT HAVE DOCUMENTED RELIABILITY PROBLEMS. SUCH PROBLEMS REDUCE THE UTILITY, EFFICIENCY, AND VALIDITY OF DESCRIPTIVE RESEARCH (CLINICAL AND EPIDEMIOLOGICAL), AS WELL AS RESEARCH ON ETIIOLOGY ...

SEVERELY SPEECH-IMPAIRED INDIVIDUALS NEED COMMUNICATION DEVICES THAT PROVIDE NATURAL-SOUNDING SYNTHETIC VOICES THAT ARE APPROPRIATE IN TERMS OF SEX, AGE, NATIONALITY, AND DIALECT. THE CREATION OF SUCH VOICES HAS BEEN HAMPERED BY HIGH DEVELOPMENT COSTS RESULTING FROM A LACK OF FLEXIBLE SOFTWARE TOOLS AND ADEQUATE LINGUISTIC MODELS FOR TEXT-TO-SPEECH SYNTHESIS. ELOQUENT TECHNOLOGY, INC. (ETI) PROPOS ...

SEVERELY SPEECH-IMPAIRED INDIVIDUALS NEED AFFORDABLE COMMUNICATION DEVICES WITH NATURAL-SOUNDING SYNTHETIC VOICES THAT ARE APPROPRIATE IN TERMS OF SEX, AGE, NATIONALITY, AND DIALECT. THE CREATION OF SUCH VOICES HAS BEEN HAMPERED BY THE HIGH COST OF DEVELOPING SPEECH SYNTHESIS SOFTWARE AND ADDING NEW VOICES, PARTICULARLY DIALECTS. WE HAVE BEEN WORKING TO REDUCE THESE DEVELOPMENT COSTS VIA (1) A NOV ...

THE OBJECTIVE OF THIS PROGRAM IS THE CREATION OF A CHILD INJURY DATA BASE FOR USE IN BIOMECHANICS RESEARCH. THE FOCUS OF THIS STUDY IS THE DEFINITION OF INJURIES OBSERVED IN YOUNG CHILDREN WHO HAVE BEEN INVOLVED IN AUTOMOBILE ACCIDENTS WHILE RESTRAINED BY CHILD RESTRAINT SYSTEMS. A SIX MONTH RETROSPECTIVE STUDY WAS PERFORMED TO CORRELATE INJURIES OF CHILD ACCIDENT VICTIMS, THE CHILD RESTRAINT DEVI ...

DEVELOPMENT OF ESTROGEN-RELATED DISEASES SUCH AS OSTEOPOROSIS, ENDOMETRIOSIS, ATHEROSCLEROSIS, AND BREAST CANCER IS RELATED TO "LIFE-STYLE" FACTORS WHICH INCLUDE DIET, REPRODUCTIVE ACTIVITY, OBESITY, AND EXPOSURE TO ENVIRONMENTAL AGENTS. THESE LIFE-STYLE FACTORS SHIFT THE BALANCE OF COMPETING ESTROGEN METABOLIC PATHWAYS, THE PRODUCTS OF WHICH EITHER PROMOTE OR INHIBIT THE PROLIFERATION OF ESTROGEN ...