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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Hepatitis B Virus Polymerase as an Antiviral Drug Target

    SBC: Avid Therapeutics, Inc.            Topic: N/A

    There are 300 million people in the world who are chronically infected with hepatitis B virus (HBV). Available therapies for the elimination of HBV infection often have a transient effect only. These therapies do not specifically target HBV, and this, in part, is a basis for their limited and variable performances. We will seek to develop targeted antiviral drugs with a particular emphasis on HBV. ...

    SBIR Phase I 1993 Department of Health and Human Services
  2. Analysis of The Organ Specific Toxicity of Chemicals

    SBC: Biofor, Inc.            Topic: N/A

    The challenge of predicting the toxic potential of chemicals has been met in the last few years by the development of sophisticated structure-activity methodologies. However, most of the endpoints studied dealt with in vitro or whole animal effects. The challenge presented by the RFP is to extend the scope of the methodologies to address the organ specific toxicity of chemicals. This is now made p ...

    SBIR Phase I 1993 Department of Health and Human Services
  3. Farnesyltransferase Inhibitors As Anticancer Agents

    SBC: Biomol Research Laboratoryt            Topic: N/A

    The goal of the research is to develop a potent, pharmacologically useful inhibitor of farnesyltransferase for use as a new therapeutic agent for cancer. The Ras family of oncogenes and proto-oncogenes encode guanine nucleotide binding proteins that participate in the control of eukaryotic cell proliferation. Ras proteins are modified posttranslationally by transfer of a farnesyl moiety to specifi ...

    SBIR Phase I 1993 Department of Health and Human Services
  4. Tyrosine Phosphatase Inhibitors As New Immunomodulators

    SBC: Biomol Research Laboratoryt            Topic: N/A

    The goal of the research is to develop a potent pharmacologically useful inhibitor of the CD45 protein tyrosine phosphatase. CD45 is a transmembrane protein having a highly glycosylated extracellular region and a cytosolic domain which possesses tyrosine phosphatase activity. CD45 plays a critical role in the activation of both T- and B-lymphocytes, thus, inhibitors of CD45 may represent new immun ...

    SBIR Phase I 1993 Department of Health and Human Services
  5. Guiding Cognitive Development¿An Expert System Approach

    SBC: Blue Lightning Data And            Topic: N/A

    In our increasingly complex society, everyday decision making requires a basic understanding of technology. To improve the science competency of American Students, educators have suggested that science and math curricula focus more on problem-solving and less on memorizing facts. We proposed to develop an expert system shell to be used to teach scientific problem-solving and other learning skills ...

    SBIR Phase I 1993 Department of Health and Human Services
  6. Biomedical Database, Text, and Idea Linker for PC

    SBC: Blue Lightning Data And            Topic: N/A

    As the size and complexity of biomedical databases increases, researchers will find it difficult to keep track of the relationships between the data and their ideas. We propose to develop a Database, Text, and Idea Linker (DTAIL) to help scientists create a personal database view. These hypertext-like tools would attach notes and comments to entries, link entries as specified by the user, and form ...

    SBIR Phase I 1993 Department of Health and Human Services
  7. Geriatric Caries Activity Test

    SBC: CHERRYSTONE CORPORATION            Topic: N/A

    This is a new approach to the development and validation of a test for assessing dental caries probability. The focus is on the detection and measurement by means of a specific physical chemical phenomenon--colloidal flocculation--due to the interaction of caries-connected extracellular polysaccharides (ECPs). Specifically produced enzymatically from sucrose by caries-associated mutans streptococc ...

    SBIR Phase I 1993 Department of Health and Human Services
  8. A PREVENTIVE HEALTH CARE PLANNING AID FOR FAMILIES

    SBC: CHI Systems, Inc.            Topic: N/A

    THIS RESEARCH WILL DEVELOP A COMPUTER-BASED AID FOR PREVENTIVE HEALTH CARE PLANNING FOR INDIVIDUALS AND FAMILIES PREVAIL (PREVENTIVE HEALTH CARE PLANNING AID FOR FAMILIES) WILL AUTOMATE THE PROCESS OF ASSESSING AN INDIVIDUAL'S MEDICAL, DEMOGRAPHIC AND LIFESTYLE CHARACTERISTICS AND MAPPING THEM ONTO A PERSONALLY TAILORED SET OF PREVENTIVE HEALTH CARE RECOMMENDATIONS. THESE RECOMMENDATIONS WILL BE B ...

    SBIR Phase II 1993 Department of Health and Human Services
  9. Quantitative Non-Instrumented Test for HDL Cholesterol

    SBC: Enzymatics, Inc.            Topic: N/A

    The research will assess and demonstrate the feasibility of constructing a dry format device for obtaining a plasma sample bearing only high density lipoprotein (HDL) cholesterol from a whole blood specimen. The long-term objective of this research is the construction of a non-instrumented diagnostic device for the quantitative determination of HDL cholesterol from a peripheral blood sample for us ...

    SBIR Phase I 1993 Department of Health and Human Services
  10. Quantitative Test for Theophylline in Saliva

    SBC: Enzymatics, Inc.            Topic: N/A

    We will demonstrate the feasibility of constructing a quantitative instrument independent diagnostic device for determination of theophylline in human saliva. Such a device is intended for medical professionals to permit them to better control and monitor treatments involving theophylline, especially asthma. Like EMIT assays, the device will utilize competitive binding of theophylline and an analy ...

    SBIR Phase I 1993 Department of Health and Human Services
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