Award Data

WE PROPOSE AN EFFICIENT AND COST-EFFECTIVE QUERY PROCESSING COMPONENT FOR AN INFORMATION RETRIEVAL SYSTEM BASED ON THE USE OF NETWORKED MICROCOMPUTERS AS A LOOSELY-COUPLED NETWORK DATABASE. THE QUERY PROCESSSING SYSTEM WILL WORK ON BOTH LOCAL AND WIDE AREA NETWORKS AND CAN BE USED WITH ANY METHOD OF INFORMATION RETRIEVAL. WE PROPOSE TO: 1. MODEL THE EXPECTED PERFORMANCE OF THIS SYSTEM SO THAT IT M ...

There are 300 million people in the world who are chronically infected with hepatitis B virus (HBV). Available therapies for the elimination of HBV infection often have a transient effect only. These therapies do not specifically target HBV, and this, in part, is a basis for their limited and variable performances. We will seek to develop targeted antiviral drugs with a particular emphasis on HBV. ...

The challenge of predicting the toxic potential of chemicals has been met in the last few years by the development of sophisticated structure-activity methodologies. However, most of the endpoints studied dealt with in vitro or whole animal effects. The challenge presented by the RFP is to extend the scope of the methodologies to address the organ specific toxicity of chemicals. This is now made p ...

The goal of the research is to develop a potent, pharmacologically useful inhibitor of farnesyltransferase for use as a new therapeutic agent for cancer. The Ras family of oncogenes and proto-oncogenes encode guanine nucleotide binding proteins that participate in the control of eukaryotic cell proliferation. Ras proteins are modified posttranslationally by transfer of a farnesyl moiety to specifi ...

The goal of the research is to develop a potent pharmacologically useful inhibitor of the CD45 protein tyrosine phosphatase. CD45 is a transmembrane protein having a highly glycosylated extracellular region and a cytosolic domain which possesses tyrosine phosphatase activity. CD45 plays a critical role in the activation of both T- and B-lymphocytes, thus, inhibitors of CD45 may represent new immun ...

In our increasingly complex society, everyday decision making requires a basic understanding of technology. To improve the science competency of American Students, educators have suggested that science and math curricula focus more on problem-solving and less on memorizing facts. We proposed to develop an expert system shell to be used to teach scientific problem-solving and other learning skills ...

As the size and complexity of biomedical databases increases, researchers will find it difficult to keep track of the relationships between the data and their ideas. We propose to develop a Database, Text, and Idea Linker (DTAIL) to help scientists create a personal database view. These hypertext-like tools would attach notes and comments to entries, link entries as specified by the user, and form ...

This is a new approach to the development and validation of a test for assessing dental caries probability. The focus is on the detection and measurement by means of a specific physical chemical phenomenon--colloidal flocculation--due to the interaction of caries-connected extracellular polysaccharides (ECPs). Specifically produced enzymatically from sucrose by caries-associated mutans streptococc ...

THIS RESEARCH WILL DEVELOP A COMPUTER-BASED AID FOR PREVENTIVE HEALTH CARE PLANNING FOR INDIVIDUALS AND FAMILIES PREVAIL (PREVENTIVE HEALTH CARE PLANNING AID FOR FAMILIES) WILL AUTOMATE THE PROCESS OF ASSESSING AN INDIVIDUAL'S MEDICAL, DEMOGRAPHIC AND LIFESTYLE CHARACTERISTICS AND MAPPING THEM ONTO A PERSONALLY TAILORED SET OF PREVENTIVE HEALTH CARE RECOMMENDATIONS. THESE RECOMMENDATIONS WILL BE B ...

SYSTEM LEVEL DESIGN DECISIONS ARE KEY TO MULTI-COMPONENT SYNTHESIS: THE DETERMINATION OF WHERE TO SPLIT THE FUNCTIONALITY AMONG COMPONENTS HAS A GREAT EFFECT ON THE SIZE AND PERFORMANCE OF THE DESIGN. BY PARTITIONING A BEHAVIOR ONTO SEPARATE MODULES EARLY IN THE DESIGN PROCESS, THE PHYSICAL IMPLICATIONS CAN BE PROPAGATED TO LATER DESIGN STAGES. DASYS PROPOSES TO DEVELOP A TOOL TO AID IN THE DESIGN ...