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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Field Localization Of Brain Generators

    SBC: ABRATECH CORPORATION            Topic: N/A

    Preliminary studies have demonstrated the feasibility of a novel computational scheme which will address critical errors in the present methodology of source localization. These studies will also make it feasible to obtain source location and pattern of activity based on realistic models of the head constructed from MRI or CT imaging modalities. Potential clinical applications include functional i ...

    SBIR Phase I 1993 Department of Health and Human Services
  2. Development of an RFQ Linear Accelerator for Clinical BNCT

    SBC: Accsys Technology, Inc.            Topic: N/A

    The primary goal of this Phase I design study is to develop the design of an accelerator-based neutron source for clinical boron neutron capture therapy (BNCT) using the compact radio-frequency quadruple (RFQ) linear accelerator. This accelerator design study will be completed in collaboration with the Brain Tumor Research Center at the University of California in San Francisco (UCSF). The acceler ...

    SBIR Phase I 1993 Department of Health and Human Services
  3. Quasimonochromatic X-Ray Source for Mammography

    SBC: ADELPHI TECHNOLOGY INC            Topic: N/A

    The objective of the program is to investigate the use of parametric x-ray radiation (PXR) as a tunable, quasimonochromatic x-ray source for mammography. PXR is generated by placing natural, synthetic crystals, or multilayer structures into the path of a relativistic electron beam. The virtual photons associated with the fields of the electrons are Bragg reflected by the periodic crystal lattice a ...

    SBIR Phase I 1993 Department of Health and Human Services
  4. Detection of Hybridization Without Radioactive Label

    SBC: ADELPHI TECHNOLOGY INC            Topic: N/A

    A novel surface phenomenon will be explored for the quantitative detection of nucleic acid hybridization. We will construct a relatively inexpensive instrument, which can attain a sensitivity limit comparable to the existing methodologies, without the use of dyes or radioisotopes. As part of the Phase I research, we will use the existing hardware to test affinity of DNA to a specifically prepared ...

    SBIR Phase I 1993 Department of Health and Human Services
  5. AIT-082; A DRUG FOR TREATMENT OF ALZHEIMER'S DISEASE

    SBC: Advanced Immunotherapeutics            Topic: N/A

    WE WILL DEVELOP AIT-082 FOR THE TREATMENT OF DEMENTIA DUE TO ALZHEIMER'S DISEASE, STROKE OR AGING. IN PHASE I, WE PLAN TO COMPLETE THE PRECLINICAL STUDIES NEEDED TO SUBMIT AN INVESTIGATION- AL NEW DRUG (IND) EXEMPTION APPLICATION TO THE FOOD AND DRUG ADMINISTRATION (FDA). SPECIFICALLY, WE WILL: (1) DETERMINE THE PRECLINICAL PHARMACODYNAMICS/ PHARMACOKINETICS OF AIT-082, (2) CONDUCT PRECLINICAL TOX ...

    SBIR Phase II 1993 Department of Health and Human Services
  6. "AN IN VITRO BIOASSAY FOR ESTROGENS AND ANTIESTROGENS

    SBC: Aeron Biotechnology, Inc.            Topic: N/A

    WE WILL DEVELOP A SIMPLE, ECONOMICAL, AND RAPID IN VITRO BREAST CANCER CELL BIOASSAY THAT CAN BE USED TO DETECT, DISTINGUISH BETWEEN, AND DETERMINE THE BIOACTIVITY OF ESTROGENS AND ANTIESTROGENS. TO DISTINGUISH BETWEEN ESTROGENS AND ANTIESTROGENS WE WILL MONITOR DIFFERENCES IN THEIR MOLECULAR ACTIONS ON ESTROGEN RECEPTOR (ER) BINDING AND ACTIVATION, ER PROCESSING, END PRODUCT INDUCTION, AND CELL P ...

    SBIR Phase II 1993 Department of Health and Human Services
  7. Phosphonium-Taxol Conjugates as Antitumor Drugs

    SBC: ANTICANCER, INC.            Topic: N/A

    Taxol is a promising new cancer agent. We will determine whether phosphonium-ion conjugates of taxol would be more effective in a patient-like animal model. It has recently been demonstrated that taxol inhibits the metastatic spread of a PC-3 human prostate tumor cell subline in a SCID (severe combined immunodeficiency) model and processes associated with metastasis (attachment, migration, proteas ...

    SBIR Phase I 1993 Department of Health and Human Services
  8. In Vitro Assays for Methionine-Dependent Chemotherapy

    SBC: ANTICANCER, INC.            Topic: N/A

    We are developing a new tumor selective treatment termed antimethionine chemotherapy. Many tumor types have been shown to exhibit an absolute requirement for methionine in vitro in order to proliferate. Normal cells and tissues can utilize homocysteine in place of methionine in order to proliferate. Methionine dependence causes methionine-dependent tumor cells to synchronously arrest in the late-S ...

    SBIR Phase I 1993 Department of Health and Human Services
  9. PURIFICATION OF PERIPHERAL BLOOD STEM CELLS

    SBC: Applied Immune Sciences, Inc.            Topic: N/A

    APPLIED IMMUNE SCIENCES, INC. HAS DEVELOPED STERILE POLYSTYRENE DEVICES ONTO WHICH MONOCLONAL ANTIBODIES ARE COVALENTLY ATTACHED. THESE DEVICES ARE ROUTINELY USED TO RAPIDLY SEPARATE CELLS WITH SURFACE ANTIGENS SPECIFIC FOR THE IMMOBILIZED ANTIBODY. MOREOVER, THESE DEVICES HAVE BEEN USED SUCCESSFULLY TO PURIFY HEMATOPOIETIC STEM CELLS FROM HUMAN BONE MARROW. THE SPECIFIC AIM OF THIS RESEARCH IS TO ...

    SBIR Phase II 1993 Department of Health and Human Services
  10. PROPAGATION OF RECOMBINANT ADENO-ASSOCIATED VIRUS VECTOR

    SBC: Applied Immune Sciences, Inc.            Topic: N/A

    RECOMBINANT ADENO-ASSOCIATED VIRUS (RAAV) VECTORS HAVE BEEN USED TO INTRODUCE GENETIC MATERIAL INTO A VARIETY OF CELL TYPES AND ARE A GOOD CANDIDATE FOR MULTIPURPOSE, SAFE DNA TRANSDUCTION SYSTEM. THE SPACIFIC AIM OF THE RESEARCH IS TO DEVELOP A SYSTEM TO VERY SIMPLY PRODUCE HIGH TITER RECOMBINANT AAV STOCKS. TO DATE, PRODUCTION OF RECOMBINANT AAV VECTORS IS A CUMBERSOME PROCESS, REQUIRING INEFFIC ...

    SBIR Phase II 1993 Department of Health and Human Services
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