Award Data

WE WILL DEVELOP AIT-082 FOR THE TREATMENT OF DEMENTIA DUE TO ALZHEIMER'S DISEASE, STROKE OR AGING. IN PHASE I, WE PLAN TO COMPLETE THE PRECLINICAL STUDIES NEEDED TO SUBMIT AN INVESTIGATION- AL NEW DRUG (IND) EXEMPTION APPLICATION TO THE FOOD AND DRUG ADMINISTRATION (FDA). SPECIFICALLY, WE WILL: (1) DETERMINE THE PRECLINICAL PHARMACODYNAMICS/ PHARMACOKINETICS OF AIT-082, (2) CONDUCT PRECLINICAL TOX ...

THIS RESEARCH WILL DEVELOP A PORT DIGITAL IMAGER (PDI). THE PDI IS A MONOLITHIC, SOLID-STATE, DETECTOR ARRAY SUBSTITUTE FOR PORT FILM. BECAUSE THE SOLID-STATE ELECTRONICS DIGITIZE THE IMAGE, IMAGING SOFTWARE CAN BE USED IN CONJUNCTION WITH THE PDI TO IMMEDIATELY ENHANCE THE IMAGE CONTRAST. AN EVALUATION OF BEAM POSITION WITH RESPECTTO BONY LANDMARKS AND SIMULATOR TREATMENT PLAN IS POSSIBLE, ONLINE ...

WE WILL DEVELOP A SIMPLE, ECONOMICAL, AND RAPID IN VITRO BREAST CANCER CELL BIOASSAY THAT CAN BE USED TO DETECT, DISTINGUISH BETWEEN, AND DETERMINE THE BIOACTIVITY OF ESTROGENS AND ANTIESTROGENS. TO DISTINGUISH BETWEEN ESTROGENS AND ANTIESTROGENS WE WILL MONITOR DIFFERENCES IN THEIR MOLECULAR ACTIONS ON ESTROGEN RECEPTOR (ER) BINDING AND ACTIVATION, ER PROCESSING, END PRODUCT INDUCTION, AND CELL P ...

APPLIED IMMUNE SCIENCES, INC. HAS DEVELOPED STERILE POLYSTYRENE DEVICES ONTO WHICH MONOCLONAL ANTIBODIES ARE COVALENTLY ATTACHED. THESE DEVICES ARE ROUTINELY USED TO RAPIDLY SEPARATE CELLS WITH SURFACE ANTIGENS SPECIFIC FOR THE IMMOBILIZED ANTIBODY. MOREOVER, THESE DEVICES HAVE BEEN USED SUCCESSFULLY TO PURIFY HEMATOPOIETIC STEM CELLS FROM HUMAN BONE MARROW. THE SPECIFIC AIM OF THIS RESEARCH IS TO ...

RECOMBINANT ADENO-ASSOCIATED VIRUS (RAAV) VECTORS HAVE BEEN USED TO INTRODUCE GENETIC MATERIAL INTO A VARIETY OF CELL TYPES AND ARE A GOOD CANDIDATE FOR MULTIPURPOSE, SAFE DNA TRANSDUCTION SYSTEM. THE SPACIFIC AIM OF THE RESEARCH IS TO DEVELOP A SYSTEM TO VERY SIMPLY PRODUCE HIGH TITER RECOMBINANT AAV STOCKS. TO DATE, PRODUCTION OF RECOMBINANT AAV VECTORS IS A CUMBERSOME PROCESS, REQUIRING INEFFIC ...

LOCAL AGENCIES AND COUNTY GOVERNMENTS ARE CONTINUALLY IN NEED OF DRUG ABUSE PREVALENCE ESTIMATES FOR PLANNING AND RESOURCE ALLOCATION. SEVERAL MATHEMATICAL MODELS EXIST, SUCH AS, MULTIPLE RECAPTURE CENSUSES AND SYNTHETIC ESTIMATORMETHODS. THESE MODELS CAN BE ADAPTED FOR USE WITH "STATE-OF-THE-ART" MICROCOMPUTING DEVICES AND SOFTWARE. APPLIED SCIENCES RESEARCH (ASR) PROPOSES TO IDENTIFY AND ADAPT M ...

DUAL ENERGY IMAGING HAS THE POTENTIAL TO ADD NEW AND POWERFUL DIAGNOSTIC CAPABILITIES TO A MEDICAL X-RAY EXAMINATION. UNLIKE AN ORDINARY X-RAY IMAGE, DUAL ENERGY IMAGE DATA CAN BE PROCESSED TO GIVE INFORMATION ABOUT THE CHEMICAL COMPOSITION OF BODY TISSUES. THIS NEW INFORMATION CAN BE USED, FOR EXAMPLE, TO ENHANCE THE DETECTABILITY OF MICROCALCIFICATIONS IN MAMMOGRAPHY OR TO QUANTIFY CALCIUM IN CH ...

BREAST CANCER IS THE PRINCIPAL CAUSE OF CANCER DEATH AMONG WOMEN IN THE UNITED STATES AND WESTERN EUROPE. IDENTIFICATION OF BREAST TUMORS THAT ARE CANDIDATES FOR ENDOCRINE THERAPY (I.E., TAMOXIFEN) HAS BEEN BASED UPON DETECTION OF ESTROGEN RECEPTORS (ER) AND PROGESTERONE RECEPTORS (PR) IN A BIOPSY. ER(-) TUMORS ONLY RARELY RESPOND TO TAMOXIFEN THERAPY, WHEREAS APPROXIMATELY HALF OF THE TUMORS SHOW ...

USING HEPARIN AFFINITY CHROMATOGRAPHY, A NOVEL FIBROBLAST AND VASCULAR SMOOTH MUSCLE CELL MITOGEN HAS BEEN ISOLATED FROM THE CONDITIONED MEDIUM OF THE HUMAN HISTIOCYTIC LYMPHOMA CELL LINE U-937. ANALYSIS OF CDNA CLONES HAS SHOWN THAT THIS FACTOR IS A NEW MEMBER OF THE EGF/TGFALPHA FAMILY OF PROTEINS, AND IT HAS THEREFORE PROVISIONALLY BEEN NAMED HEPARIN-BINDING EGF-LIKE GROWTH FACTOR (HBEGF). AMPL ...

A NOVEL AUTOMATED REHABILITATION CYCLE (ARC) DEVICE HAS BEENBUILT FOR ALTERNATING UPPER/LOWER EXTREMITY REHABILITATION (ACTIVE/PASSIVE MOTION) WITH PARTICULAR APPLICATION TO THE GERIATRIC BEDRIDDEN POPULATION. THE DEVICE IS CAPABLE OF REPLACING MANY LABOR-INTENSIVE REHABILITATION PROCEDURES WITH AUTOMATED THERAPY IN A WIDE VARIETY OF CLINICAL CONDITIONS. THIS SINGLE MACHINE IS CONSIDERABLY MORE VE ...