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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. SBIR Phase I: Novel, Robust Process for Thin, Dense Ceramic Coatings

    SBC: Solution Spray Technologies, LLC            Topic: MI

    This Small Business Innovation Research Phase I project is aimed at development of a novel, low-cost process for manufacturing environmental barrier coatings (EBCs) for ceramic matrix composites (CMCs) in aviation gas turbines. A key limitation for CMC adoption is the unavailability of inexpensive, truly gas impervious EBCs to provide required CMC engine service life. While novel EBC compositions ...

    SBIR Phase I 2017 National Science Foundation
  2. Assembled Porous Silica Membranes for Biomolecule SPE

    SBC: ADVANCED MATERIALS TECHNOLOGY, INC.            Topic: 400

    Abstract Life sciences research and other critical bioanalytical applications would strongly benefit from faster and higher efficiency sample preparation processes Sample preparation before high resolution analytical methods such as HPLC or LC MS can require effort and cost nearly equivalent to the actual sample analysis and data reduction Often sample preparation for proteomic glycoproteom ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Developing an integrated sorting and single cell analysis tool for the analysis of rare T Cells subsets in Autoimmunity

    SBC: IsoPlexis            Topic: R

    Autoimmune disease AD affects up to million Americans which costs approximately $ billion on health care annually and accounts for one of the leading causes of death in women T cells and cytokine function play an important role in autoimmune diseases such as Type Diabetes Multiple Sclerosis Rheumatoid Arthritis RA and Systemic Lupus Erythematosus SLE The most successful auto i ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Precision quality check of immunotherapeutics via single-cell cytokine mapping

    SBC: IsoPlexis            Topic: 102

    Adoptive transfer of autologous T cells engineered to express chimeric antigen receptorsCARshas emerged as a promising immunotherapy for patients with hematologic malignanciessuch as CDCARs in leukemias and lymphomasHoweverchallenges remain in terms of manufacturing consistency and the functional profile of the CAR T cell productsince infused cellsasliving drugscan be activated and release a varie ...

    SBIR Phase II 2017 Department of Health and Human Services
  5. Osteopontin targeted therapy for primary CNS lymphoma

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    Abstract Primary central nervous system lymphoma PCNSL is an aggressive brain tumor with a dire unmet therapeutic need It has an overall incidence of per person years and is regarded as an orphan disease with potential for fast track approval Our group made a discovery via gene expression analysis that osteopontin OPN is the most upregulated gene in PCNSL compared to its non CNS ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Robust Predictor of Breast Cancer Risk

    SBC: Morgan and Mendel Genomics, Inc.            Topic: 103

    Summary Approximatelymillion women in the United States are at high risk for developing breast cancerbased on inheritance of a germline mutation in a gene in the double strand breakDSBrepair and cyclin checkpoint pathwaysMany are unaware of their genetic predispositionsbecause their family history is uninformative or unknownGenetic testing is important for identifying mutations in these genesbut i ...

    STTR Phase I 2017 Department of Health and Human Services
  7. Developing Multi-targeting Antiviral Agents Against Herpes Simplex 1

    SBC: Quercus Molecular Design, LLC            Topic: NIAID

    Viruses from the human herpesvirus family are estimated to infectof the adult population worldwide and are responsible for lifelong debilitating and congenital infectionsSome members of this family are associated with human cancers and age related cognitive declineHerpes simplex virusHSVhas infected more thanbillion people under the age ofof the populationHSVcauses significant disease during acute ...

    STTR Phase I 2017 Department of Health and Human Services
  8. A single-cell device to capture and analyze rare T-cells from solid tumors.

    SBC: IsoPlexis            Topic: 102

    Checkpoint inhibitors towards targets such as PDand PD Lare being developed to activate quiescent T cells embedded in tumors and enable them to recruit the rest of the immune system to fight a cancer massHow these new cures reactivate the relatively few Tumor Infiltrating LymphocytesTILsenabling the release of a complex message of cytokines to recruit the immune systemthus impacting treatment effi ...

    SBIR Phase II 2017 Department of Health and Human Services
  9. Development of PEGylated MTI for the treatment of relapsed Myeloma

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    ABSTRACT Modulation Therapeutics is developing a first in class cyclic peptide coined MTI for the treatment of multiple myeloma The company currently has a license for the parent molecule which has been awarded a patent covering the intellectual property for both composition of matter and use in cancer in the US and Europe Modulation Therapeutics is now poised to further advance this class ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. A Single-Cell Device to Detect Pathogenic Cell Populations in Bone Marrow Disease

    SBC: IsoPlexis            Topic: NIBIB

    MyelofibrosisMFbelongs to a group of closely related chronic blood diseasesmyeloproliferative disordersMPDMost MF patients have no symptoms or present with nonspecific constitutional symptomsweight lossfatigueas such an early stage diagnosis of MF is challengingMF is clinically suspected when patients present with an enlarged spleen and or with anemiathrombocytopeniaor leukopenia leukocytosishowev ...

    SBIR Phase II 2017 Department of Health and Human Services

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