Award Data

DECRIPTION (Provided by applicant): Pyrogen-free water (PFW) is required in many applications. Laboratories use it as solvent for compound preparation, culture media, and equipment rinse. Hospitals use it for cleaning to prepare solutions for injections, lV's, and hemodialysis. Pharmaceutical manufacturers use it to formulate injectable drug preparations. Pyrogens, or fever-inducers, are derived f ...

A new class of antimicrobials based on dendrimer technology has been identified and shown to possess potent biocidal activity. Laboratory evaluation of these polycationic dendrimers has shown that they are more than 100 times more effective than a comparable amount of free quaternary ammonium compound at killing Esherichia coli. Potent activity against Staphylococcus aureus has also been demonstra ...

DESCRIPTION (provided by applicant): Total Artificial Heart (TAH) and related devices (e.g., ventricular assist device) are emerging that provide the potential for almost unlimited patient mobility and near-normal lifestyle for the patient. The new devices being developed are totally implantable, self-contained (battery is external), electrically driven systems. However, the power and energy densi ...

DESCRIPTION (provided by applicant): High-content screening (HCS) via high-resolution fluorescence cellular microscopy is a powerful technology for drug discovery and is currently being used in secondary screening and optimization of candidate compounds. The aim of Cytoprint's proposed effort is to demonstrate advanced image analysis informatics tools to address critical bottlenecks in the deploym ...

DESCRIPTION (provided by applicant):InLight Solutions is actively developing a compact, robust, noninvasive acid-base status monitor that rapidly assesses patient acid-base status at the point-of-care. We have proven technical feasibility of the technique through in vitro studies using human blood samples. In these studies, our instrument measured pH, bicarbonate ion, and pC02 with clinically rele ...

RGMT?s long-term objective is to develop a low-cost, handheld, rugged, field-deployable noninvasive alcohol measurement system for law enforcement, workplace, research, and clinical settings. The system will optimize, for EtOH, an optical spectroscopy technology platform developed to non-invasively measure glucose levels. Initial experiments measuring alcohol demonstrate accuracy levels that excee ...

DESCRIPTION (provided by applicant): In Phase I Kestrel Corporation developed and demonstrated a retinal imaging system that combines multispectral imaging techniques with adaptive optics and image deconvolution to provide high resolution less than (

DESCRIPTION (provided by applicant): In Phase I Kestrel Corporation developed and demonstrated a retinal imaging system that combines multispectral imaging techniques with adaptive optics and image deconvolution to provide high resolution less than (

Glaucoma is a chronic disease whose causes are not well understood. It is estimated that three million Americans have glaucoma, and 67 million people worldwide will have glaucoma by the year 2000. At least half do not know they have it because glaucoma usually has no symptoms in the early stages. Untreated, glaucoma is a leading cause of irreversible blindness. An important goal of ...

DESCRIPTION: Recently, New Photonics LLC (NP) demonstrated that newly developed blue Light Emitting Diodes (LEDs) used in continuous mode can provide up to 4 mm depth of cure in Dental composite resin in about 2 minutes of exposure. Despite its many advantages, the commercial viability of this LED-based technology would be significantly enhanced if the time of exposure necessary for curing is redu ...