Award Data

DESCRIPTION (provided by applicant): Cervical cancer is one of the most common cancers affecting women and is a worldwide health problem. Unlike most cancers, cervical cancer is caused by a virus - the human papillomavirus (HPV). Two preventative vaccines against HPV were recently licensed in the United States. Merck and Co. developed a vaccine called Gardasil(tm) and GlaxoSmithKline has develop ...

DESCRIPTION (provided by applicant): SCR, Inc. (Louisville, KY) has developed a long-term implantable counterpulsation device (CPD) to treat heart failure (HF) patients who may be responsive to a milder form of cardiac assist. The CPD is 32-ml stroke vol ume, valveless pneumatically-driven blood sac with a single inflow/outflow cannula. The sac fits ergonomically in a pacemaker pocket' and the ...

DESCRIPTION (provided by applicant): The objective of this Compact Membrane Systems (CMS) program is to develop a new platform technology for fire suppression and fire prevention systems around membrane supplied nitrogen enriched air (NEA). The limitation that the atmospheres used in the fire suppression be breathable to occupants in the proximity of a fire is easily accomplished by CMS technolog ...

DESCRIPTION (provided by applicant): Sickle Cell Disease (SCD) is a genetic abnormality of red blood cells (RBC) that affects over 70,000 people in the United States, or approximately 1 in every 500 African-Americans. With current therapies, the mortality in the United States is 50% by age 40. SCD is a chronic, debilitating disease associated with frequent painful crises, acute chest syndrome, st ...

DESCRIPTION (provided by applicant): Warfarin is the most commonly used oral anticoagulant medication. Because an individual's proper warfarin dose is difficult to assess, most physicians initiate therapy at a standard dose and follow up with an INR blood test to ensure the medicine is working properly. Unfortunately, therapeutic warfarin doses vary significantly from patient to patient, so that ...

DESCRIPTION (provided by applicant): This Phase II SBIR project proposes to develop an electrical stimulation augmented exercise device for individuals with incomplete spinal cord injury (iSCI). The device will provide a closed-chain, load bearing lower extremity exercise that has the potential to condition muscles and reverse or slow the rate of loss of bone mineral density. Users will be enc ...

DESCRIPTION (provided by applicant): The purpose of this Phase II STTR project is to develop a nanoparticle-based drug delivery system for use in the treatment of dry age-related macular degeneration (AMD). AMD is the leading cause of blindness for individ uals over fifty-five years of age that live in the industrialized world, affecting approximately 10 million people in the US and as many as 30 ...

DESCRIPTION (provided by applicant): Tissue and organ transplantation procedures save and/or improve the lives of hundred of thousands of patients annually in the US. The goal of this research is to develop a local anti-complement therapy for donor organ e x vivo application that will reduce complement-induced injury to the vascular endothelium. An unavoidable consequence of transplantation (allog ...

DESCRIPTION (provided by applicant): The objective of this NIAID Advanced STTR Phase I proposal is to combine the strengths of academic investigators from the fields of immunology and animal disease modeling with the resources of ApoImmune Inc. to develop a novel vaccine, ApoVax104-TB targeting both active and latent Tuberculosis (TB) infections. ApoVax104-TB uses a novel proprietary vaccine ba ...

DESCRIPTION (provided by applicant): There is a national need for conflict resolution and peace education. Skit-based performances and open discussion are two frequently successful methods of working with children to develop conflict resolution skills. This project is creating a core set of conflict resolution modules along with ongoing new video-scenarios and educational materials that explore va ...