Award Data

The proposed research and development activities will determine the scientific, technical, and commercial feasibility of the use of solvent-free liquid polymer-grafted surface wipes as novel materials that more efficiently removes low volatility chemical agent contamination from porous and absorptive surfaces than current materials.. The polymers will be able to extend into pores and dissolve the ...

The current practice of training canines for explosives detection utilizing actual explosives requires qualified personnel that are trained to handle explosive materials making the training both manpower-intensive and costly. The expense is further exacerbated by the need to handle and dispose of the explosive material according to local, state, and federal explosives regulations. Finally, the nat ...

Single chirality of single-walled carbon nanotubes (SWCNTs) is critical for their superb mechanical, thermal, optical and electronic properties. All known methods for producing nanotubes give mixtures of tubes with different chiralities. Physical separation of SWCNT by chirality is thus an enabling step for many potential applications and fundamental studies. The existing anion exchange resins are ...

This Small Business Innovation Research (SBIR) Phase II project will design, build, test, and validate a fully operational prototype disk drive incorporating a commutational ramp load actuator (CRLA). The CRLA is a unique and transformative actuator for disk drives that provides significant improvements over existing actuator technology by increasing performance and reducing cost. The research obj ...

DESCRIPTION (provided by applicant): Age-related macular degeneration (AMD) is a sight-threatening disease which represents the leading cause of blindness and visual impairment in elderly individuals in developed countries. Recently, laser and photodynamic therapies with limited clinical benefit have been partially replaced by anti-vascular endothelial growth factor (VEGF) therapies. Clinical ...

DESCRIPTION (provided by applicant): This Small Business Innovation project aims to develop an innovative eye drop formulation for the treatment of glaucoma and ocular hypertension. Charlesson has acquired from Danube Pharmaceuticals MSH-1001, a new smallmolecule compound (previously known as DNB-001 or KR- 31378). MSH-1001 is has both ocular hypotensive and neuroprotectant properties. It is an AT ...

DESCRIPTION (provided by applicant): Transition metal catalysts are widely used in the pharmaceutical industry for the production of active ingredients, precursors and new drug candidates. These products must be very pure, often requiring labor and energyintensive separation processes, to achieve the required purity levels. Of special concern in the present context is to avoid contaminating the pr ...

DESCRIPTION (provided by applicant): The overall focus of this application is to develop nanofiltration membranes to recover the spent solvents generated from drug manufacturing processes allowing the solvents to be reused resulting in elimination of waste. This is also responsive to NIH RFP PA-09-100 entitled Energy Efficiency and Renewable Energy System Technology Research and Development . By ...

DESCRIPTION (provided by applicant): Analysis of glycoprotein polypeptide sites of carbohydrate attachment and the structures of the glycans present on these proteins requires the combination of high resolution chromatographic separations and sophisticatedmass spectrometry. Hydrophilic interaction liquid chromatography (HILIC) has great use in separations of glycopeptides and released glycans, exh ...

DESCRIPTION (provided by applicant): Life sciences research and other critical bioanalytical applications would strongly benefit from faster and higher resolution liquid chromatographic (HPLC) separations for both small molecules and larger molecules suchas proteins, peptides, glycopeptides, and glycans. Many HPLC separations of biomedical interest, such as proteomic or glycomic profiling, require ...