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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Packaging High Power Photodetectors for 100 MHz to 100 GHz RF Photonic Applications

    SBC: PHASE SENSITIVE INNOVATIONS            Topic: AF131142

    ABSTRACT:In this phase II effort we will commercialize the high speed, high power, modified uni-traveling carrier (MUTC) photodiodes (PDs). To this end, we will develop reliable packaging solutions for discrete PDs, PD arrays, balanced PDs and waveguide based PDs. We will also transition the chip fabrication process for continuous, high volume supply of quality MUTC PD chips. In the first six mont ...

    SBIR Phase II 2015 Department of DefenseAir Force
  2. A Phase a clinical trial of ALK in geographic atrophy

    SBC: ALKEUS PHARMACEUTICALS, INC.            Topic: NEI

    DESCRIPTION provided by applicant The long term goal of this work is to develop an oral drug for the prevention of age related macular degeneration AMD AMD is the leading cause of blindness in the United States with million Americans diagnosed or at risk of irreversibly losing vision and over million people who already have debilitating vision loss Currently there is no FDA approved ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  3. A single-cell device to capture and analyze rare T-cells from solid tumors.

    SBC: IsoPlexis            Topic: 102

    Checkpoint inhibitors towards targets such as PDand PD Lare being developed to activate quiescent T cells embedded in tumors and enable them to recruit the rest of the immune system to fight a cancer massHow these new cures reactivate the relatively few Tumor Infiltrating LymphocytesTILsenabling the release of a complex message of cytokines to recruit the immune systemthus impacting treatment effi ...

    SBIR Phase II 2017 Department of Health and Human Services
  4. Precision quality check of immunotherapeutics via single-cell cytokine mapping

    SBC: IsoPlexis            Topic: 102

    Adoptive transfer of autologous T cells engineered to express chimeric antigen receptorsCARshas emerged as a promising immunotherapy for patients with hematologic malignanciessuch as CDCARs in leukemias and lymphomasHoweverchallenges remain in terms of manufacturing consistency and the functional profile of the CAR T cell productsince infused cellsasliving drugscan be activated and release a varie ...

    SBIR Phase II 2017 Department of Health and Human Services
  5. Silicon Receiver for Millimeter Wave Distributed Aperture Imager with Optical Upconversion

    SBC: PHASE SENSITIVE INNOVATIONS            Topic: SB113003

    In this Phase II SBIR effort we will dramatically reduce the size, weight, and power requirements of a passive millimeter wave imaging system based on optical upconversion. To this end, we will integrate custom silicon-germanium low noise amplifiers that have been designed to efficiently couple with our high performance lithium niobate upconversion modules. In Phase I we analyzed the design requ ...

    SBIR Phase II 2012 Department of DefenseDefense Advanced Research Projects Agency
  6. A Single-Cell Device to Detect Pathogenic Cell Populations in Bone Marrow Disease

    SBC: IsoPlexis            Topic: NIBIB

    MyelofibrosisMFbelongs to a group of closely related chronic blood diseasesmyeloproliferative disordersMPDMost MF patients have no symptoms or present with nonspecific constitutional symptomsweight lossfatigueas such an early stage diagnosis of MF is challengingMF is clinically suspected when patients present with an enlarged spleen and or with anemiathrombocytopeniaor leukopenia leukocytosishowev ...

    SBIR Phase II 2017 Department of Health and Human Services
  7. Electro-Optically Guided Radar Imaging

    SBC: PHASE SENSITIVE INNOVATIONS            Topic: A13040

    Herein, PSI proposes to leverage extensive development in the area of optically sampled passive millimeter-wave imaging to develop dual mode active/passive imagers that provide both the intuitive, real-time imagery of a passive imager and the ranging capabilities of an active sensor. To accomplish this task, an optically sampled millimeter-wave receive array is sampled via optical pulsed laser gat ...

    SBIR Phase II 2015 Department of DefenseArmy
  8. Novel Nanofiltration Membranes for Isolation of Pharmaceutical Compounds II

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: 300

    DESCRIPTION provided by applicant In the manufacture of pharmaceutical compounds organic syntheses are often carried out in organic solvents These solvents must then be separated from high value intermediates and active pharmaceutical ingredients APIs in order to produce the final product medications Many intermediate compounds and APIs are thermally labile and thermal separation processes ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Functional Dataflow Programming Toolchain for Portable Parallel Code

    SBC: EM PHOTONICS INC            Topic: SB151004

    Modern computer systems often incorporate multiple computational devices such as conventional processors, graphics processing units (GPUs), specialized accelerators, and field-programmable gate arrays (FPGAs). Programmers are able to exploit these new architectures for improved performance and reduced power consumption, but at the cost of increased programing complexity. Further complicating matte ...

    SBIR Phase II 2016 Department of DefenseDefense Advanced Research Projects Agency
  10. Enhanced Realtime Millimeter Wave Imaging Using Hardware Acceleration- CPP

    SBC: EM PHOTONICS INC            Topic: N06079

    The ultimate goal of this Commercialization Pilot Program (CPP) effort is to design, build, and integrate flight-ready custom electronics for a 220-channel MMW distributed-aperture imager. This work bases on a previous SBIR project, in which we constructed a single-channel prototype of the phase control electronics in a laboratory (breadboard) environment. To enable control of a 220-channel system ...

    SBIR Phase II 2010 NavyDepartment of Defense

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