Award Data

To address the Chemical and Biological Defense (CBD) need for a residual life indicator (RLI) capable of determining the degradation in physical adsorption and reactive capacity arising from battlefield contaminants and exposure to the elements, Physical Optics Corporation (POC) proposes to continue the development of a new Miniature Residual Life Indicator (MRLIN). MRLIN is based on impedance spe ...

To address the CBD need for improved formulations to enhance the ease of use and bioavailability of antisense therapeutics, Physical Optics Corporation (POC) proposes to advance development of a Multifunctional Antisense Therapeutics Nanocarrier and Inhalation Device (MATEN). This proposed system is based on a new dry powder formulation and a novel design of an inhaler that uses mature components ...

Poor drug candidates are often identified late in the drug development process (e.g., in the preclinical and clinical phases) and contribute significantly to the high cost and low yield of drug discovery. As a result, new tools are needed to accelerate the assessment of drug candidate toxicity earlier in the drug development process. To address this Chemical/Bio Defense (CBD) need, Physical Optics ...

Redondo Optics Inc. (ROI), proposes to develop and demonstrate a next generation integrated electrophoretic nanofluidic biochip (INTRay-Nanochip) sensor platform for the"label-less"THz spectroscopy finger printing of biological species and agents. In the proposed Phase II of this program, ROI will focus on the engineering development of a manufacturable optical nanolithography technology to enable ...

There is a critical need for rapid, accurate measurement of serum cholinesterase activity in the field to provide a timely determination of nerve agent exposure. The overall objective of the project is to develop an easy-to-use analytical system consistingof small, inexpensive (and therefore disposable) silicon microchips used with a portable instrument, thus permitting field cholinesterase measur ...

The early genomic responses of human peripheral blood mononuclear cells (PBMCs) to in vitro infection with specific microbial pathogens are being assessed by DNA microarray technology to determine host gene expression

A thermal infrared imaging spectrometer is proposed for the remote detection and identification of surface contaminants. The instrument will use a high power, pulsing CO2 laser to vaporize the liquids while it scans the target scene generating 3Dspectral-images. The instrument will be pre-programmed with a library of contamination filters that can automatically identify contaminants that could b ...

This Small Business Innovation Research Phase I project will develop a non-animal based in-vitro assay for determining the efficacy of Botulinum (BoNT) neutralizing therapeutics; the dual nanopore assay (DNPA). New technologies are currently needed in order to facilitate the development and approval of BoNT vaccines and therapies, and align with the NIH and FDA"s guidance for reducing/replacing th ...

This Small Business Innovation Research Phase I Project ? is primarily to investigate the chemical and biological protective properties of nano-additives in bulk and in polymers. Conventional chemical and biological protective materials are based onactivated carbon, polymers and their combinations. Their mechanism of protection is based on adsorption and impermeability, respectively, and does not ...

Raman spectroscopy is a highly effective non-contact laser remote sensing method for detecting and identifying chemicals in every-day field environments. Raman spectroscopy is particularly suited for detecting trace surface contaminants that may indicate the presence of explosives, harmful chemical or biological agents. Contemporary systems, such as the vehicle mounted Joint Contaminated Surface D ...