Award Data

GeneCapture, Inc. is proposing to develop a rapid in vitro diagnostic prototype using our patented molecular-based CAPTURE (ConfirmActive Pathogens Through Unamplified RNA Expression) assay. Based on the results and experience gained in our Phase I STTR contractHDTRA1-16C-0061: Infectious Disease Diagnostics and Differentiation of Viral vs. Bacterial Infections for Point of Care Applications, we p ...

Blast induced Traumatic Brain Injury (TBI) is a major threat to the health of military personnel serving in modern theaters. As such, the biomechanical injury pathways of TBI are, and have been, the focus of many animal studies. However, differences in the experimental setups across laboratories make it difficult to draw definitive conclusions from the resulting data. A tool that can accurately es ...

The objective of this Phase II project is to translate the proof of concept prototype developed in Phase I towards practical implementation. The focus will be on transtibial prosthetic legs. The Phase I design will be improved for bio-mechanical functionality, reliability and cost effectiveness. Full size and full load scale products will be experimentally tested and evaluated with transtibial amp ...

Complete human anatomy avatars have a broad role in advanced training environments, performance-related physiological modeling, and simulations for the purpose of designing protective armor. The overall goal of this project is to design and develop computer software and data structures for adding articulated joints and natural motions to USARIEMs static finite element avatars and to create a graph ...

The Aerial Reconfigurable Embedded System (ARES)allowsalarge payload to beindependently configured to meet themission needs. This PhaseIIeffort will develop amission payload for use on the DARPA ARES Technology Demonstrator fora Casualty Evacuation (CASEVAC) Module. Under thiseffort the PiAC team willevaluatetheexisting pod structureto assess theintegration ofasinglelitter,medical crew personnelan ...

Interfaces on existing military chemical/biological protection garments are not designed to fully eliminate macroscopic and microscopic air gaps at folds, fabric surfaces, or hook-and-loop closures, and thus do not provide a hermetic barrier against exposure. Creare is developing hermetic garment closure systems that seal macroscopic and microscopic gaps at interfaces and closures and provide high ...

Future engagements (especially with near-peer threats) present the possibility of a wide range of anticipated operational situations involving the presence of chemical threat agents. With this, deployment of Military Working Dogs (MWDs) is likely. This creates a situational awareness that MWDs are potentially at risk from exposure to a wide range of hazardous chemicals. Potential threat agents inc ...

Alphaviruses, infection with which may cause encephalitis and death, are recognized as potential biological warfare agents. There are noapproved medical countermeasures against Alphaviruses. In Phase I, using Abzymes proprietary in vivo Self-Diversifying Camelid SingleDomain Antibody Library (SDALib) platform, broadly reactive single domain camelid VHH antibodies against equine encephalitis viral ...

Current high-throughput platforms rely on labeled substrates that produce detectable spectroscopic signals upon reaction for monitoring enzyme catalytic activity. Add to that the high price tag for these instruments, ranging from several hundred thousand to millions of dollars, and there is a clear need for alternate solutions for a label-free, low-cost, high-throughput enzyme screening platform. ...

Current drug discovery and development efforts are severely limited by expensive animal trials and oversimplified in vitro models. Results obtained from in vitro models are not predictive of in vivo toxicity owing to significant difference from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device that reproduces the physiological ...