Award Data

Despite over 100 years of research, decompression sickness (DCS) remains the mission-limiting factor in the design and execution of combat diving operations.Divers may spend over an hour decompressing after spending as little as ten minutes at the target depth.While decompressing, divers are limited in vertical mobility, making then susceptible to detection and threatening their survivability.This ...

Current drug discovery and development efforts are severely limited by expensive animal trials and oversimplified in vitro models. Results obtained from in vitro models are not predictive of in vivo toxicity owing to significant difference from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device that reproduces the physiological ...

We propose to demonstrate a"Tracking with Planning"module for tracking objects in a highly cluttered environment from a moving platform. This system is designed to track objects with multiple long occlusions, by anticipating where and how the objects might move. The main innovations are 1) actively anticipating objects'goals and intentions, 2) using motion planning to create multiple plausib ...

High-speed flight vehicles commonly use carbon / carbon (C/C) and carbon / silicon carbide (C/SiC) for structural components. These materials are chosen because of their superior structural properties at elevated temperatures. Most often, their properties are characterized using flat and thin material test plates. While this approach is convenient, it is not guaranteed to yield material properties ...

Interfaces on existing military chemical/biological protection garments are not designed to fully eliminate macroscopic and microscopic air gaps at folds, fabric surfaces, or hook-and-loop closures, and thus do not provide a hermetic barrier against exposure. Creare is developing hermetic garment closure systems that seal macroscopic and microscopic gaps at interfaces and closures and provide high ...

The purpose of this contract is to develop high affinity antibodies that are specific to Burkholderia surface expressed polysaccharides. These monoclonal antibodies (mAbs) can then be used to develop diagnostics and therapeutics for melioidosis and glanders; two infectious diseases caused by the Tier 1 biothreats Burkholderia pseudomallei and mallei, respectively. The SBIR funded work to date deve ...

We propose to create transformative technologies to overcome several CRISPR-wide challenges that will broadly enable scalable, multiplexable gene editing & gene regulation with minimal off-target activity. Our technical solutions combine computational design of optimal CRISPR components, genetic circuits, and RNPs together with experimental validation. We will implement several demonstrative appli ...

GeneCapture, Inc. is proposing to develop a rapid in vitro diagnostic prototype using our patented molecular-based CAPTURE (ConfirmActive Pathogens Through Unamplified RNA Expression) assay. Based on the results and experience gained in our Phase I STTR contractHDTRA1-16C-0061: Infectious Disease Diagnostics and Differentiation of Viral vs. Bacterial Infections for Point of Care Applications, we p ...

The objective of the proposed project is to develop designs for manufacturable all-metal terminal hot-electron transistors (AMTHETs) that will enable 1W – 10W THz RF amplifiers and oscillators. The proposed work will focus on quantum-mechanical modelin...

Alphaviruses, infection with which may cause encephalitis and death, are recognized as potential biological warfare agents. There are noapproved medical countermeasures against Alphaviruses. In Phase I, using Abzymes proprietary in vivo Self-Diversifying Camelid SingleDomain Antibody Library (SDALib) platform, broadly reactive single domain camelid VHH antibodies against equine encephalitis viral ...