Award Data

The skin is the first line of defense against chemical warfare agents including nerve agents and toxic industrial chemicals, providing a possible barrier or delay to systemic distribution. Some chemicals also can act directly on the skin including the vesicants sulfur mustard and lewisite. Early and rapid skin decontamination is extremely important following exposure to CWAs and TICs because it de ...

GeneCapture, Inc. is proposing to develop a rapid in vitro diagnostic prototype using our patented molecular-based CAPTURE (ConfirmActive Pathogens Through Unamplified RNA Expression) assay. Based on the results and experience gained in our Phase I STTR contractHDTRA1-16C-0061: Infectious Disease Diagnostics and Differentiation of Viral vs. Bacterial Infections for Point of Care Applications, we p ...

This SBIR Phase II project will create an industrial process for bonding ceramics to metals at the molecular level. Attempts thus far have not been successful in creating robust bonds due to incongruities of the materials being bonded. The objective of this project is to develop a sophisticated, computer controlled, automated bonding machine that will rapidly and safely impact-bond net-shaped cera ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project has the potential to help enhance disease resistance in poultry and increase yields due to the delivery of only healthy, fully vaccinated chicks to farms. These healthier chicks will reduce the need for antibiotics in poultry, aiding to combat antimicrobial resistance. This technology has imm ...

Interfaces on existing military chemical/biological protection garments are not designed to fully eliminate macroscopic and microscopic air gaps at folds, fabric surfaces, or hook-and-loop closures, and thus do not provide a hermetic barrier against exposure. Creare is developing hermetic garment closure systems that seal macroscopic and microscopic gaps at interfaces and closures and provide high ...

THIS PHASE I EFFORT WILL APPLY THEORETICAL METHODS BASED PRINCIPALLY ON CAGNIARD'S FORMALISM (PREVIOUSLY INCORPORATED BY US INTO OUR POWERFUL SWREF CODE), TO THE PROPAGATION AND FOCUSING, IN BOTH REFLECTIVE AND PHASED-ARRAY EQUIPMENT, OF SHOCK-WAVES PRODUCED BY UNDERWATER SPARKS. THE OBJECTIVE IS TO INVESTIGATE AND PROVIDE DESIGN DATA FOR LITHOTRIPSY EQUIPMENT IN WHICH FOCUSED SHOCK WAVES ARE USED ...

CONVENTIONAL ROCK CORE DRILLING AT GREAT DEPTHS IS EXTREMELY EXPENSIVE AND TIME CONSUMING. ITS MAJOR DRAWBACK IS THE REQUIRED LENGTH OF DRILL PIPE. THE SUSPENSION CORE DRILL IS SUPPORTED BY CONTINUOUS FLEXIBLE LEADS HELD ON ONE OR MORE HIGH-SPEED REELS. WITHDRAWALS AND REPLACEMENT TIMES CAN BE REDUCED BY AN ORDER-OF-MAGNITUDE. COMMERCIAL USES INCLUDE STANDARD CORING APPLICATIONS AS WELL AS INTERMI ...

RESEARCH AND DEVELOPMENT WILL BE CARRIED OUT TO PROVIDE PROTOTYPE, ACTIVELY CONTROLLED GAS BEARINGS FOR PRECISION MOVEMENT IN INSTRUMENTS AND MACHINE TOOLS. THIS WILL DRAW UPON PRELIMINARY WORK ON (1) FABRICATION, (2) DYNAMIC ANALYSIS OF THE BEARING AND SUPPORTED MASS, (3) PIEZOELECTRIC VALVING AND PIEZOELECTRIC DISPLACEMENT OF THE BEARING SURFACE, AND (4) THE ADAPTATION OF A MICROPROCESSOR TO SER ...

THE RECENT DEVELOPMENT OF MOLECULAR BIOLOGY, PARTICULARLY INTHE FIELD OF RECOMBINANT DNA TECHNOLOGY, GIVES BIRTH TO A NEW ERA IN MEDICAL THERAPEUTICS AND DIAGNOSTICS USING PRODUCTS FROM MAMMALIAN CELL CULTURE. FOR EFFECTIVE RESEARCH AND CLINICAL USE, THESE PRODUCTS NEED TO BE MANUFACTURED IN LARGE QUANTITIES AND AT A TOLERABLE COST. TODAY PRODUCTION COSTS ARE VERY HIGH. THIS PROPOSAL IS PARTOF AN ...