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ImmuNext has defined an anti-MCT1 monoclonal antibody (mAb) that will be developed for the treatment of human autoimmune disease. The membrane monocarboxylate nutrient transporter SLC16A1 (MCT1) is a multi-pass transmembrane protein responsible for the facilitated transport of critical metabolites, including products of glycolysis: lactate, pyruvate and ketones. Our strong preliminary data support ...

The current state of the art thermal battery technologies will not be able to meet future requirements that call for higher power and capacity with a smaller footprint. The principal avenue for increasing the capacity of thermal battery is to identify and develop new electrode materials that provide higher specific capacity and power performance. The overall objective of the proposed effort is to ...

Missiles and munitions require, in the absence of gunner input, an autonomous capability to discriminate between hard targets such as Rolled Homogeneous Armor (RHA) and various other softer targets on impact in real-time. The proposed program will integrate multiple sensing techniques and devices into a single system to realize a robust target discrimination capability. The effort will quantify th ...

PROJECT SUMMARY Sclerodermasystemic sclerosisSScis an autoimmune disease of unknown etiology that is characterized by vascular dysfunctionfibrosisand inflammationOne in three patients dies withinyears of diagnosisgiving SSc the highest case fatality rate of any systemic autoimmune diseaseA lack of biologically relevant SSc disease models has created a critical unmet need for more efficient preclin ...

PROJECT SUMMARY ABSTRACTMillions of children around the globe are afflicted with conditions that can alter neuropsychological developmentincluding human immunodeficiency virusHIVtraumatic brain injuryTBIcerebral malariaand a host of other developmental and acquired diseases and disordersEarly assessment and intervention are critical in overcoming cognitive and developmental deficiencies and are in ...

PROJECT SUMMARY ABSTRACT The National Research Council recognizes that serious computer games can support new inquiry based approaches to science instructionproviding virtual laboratories or field learning experiences that overcome practical and logistical constraints to student investigationsWith the nationally recognized need to encourage and enhance education in the ScienceTechnologyEngineering ...

The over arching goal of this proposed SBIR driven program is to create relevant DiscoveryBioMedDBMhuman cellular toxicityHCTplatforms for the kidney grown inD and inD cell culture formats for a newgold standardin lead therapeutic asset and materials in vitro testing and to reduce markedly the need for and the number of animals used in preclinical testingPrimary cultures of different human cell ty ...

NODA Telehealth system improves access to an autism diagnostic assessment by guiding families to share video clips of their child at homeso diagnostic clinicians can directly observe andtagvideo of any atypical behaviorand if warrantedrender a diagnosisThis system is evidence based and has been commercializedwith several published studies to discuss the benefitsWe now propose to improve this servi ...

Fuel applications for scramjet powered flight greater than Mach 8 require the injection, mixing and combustion process to complete in a very short period of time. The one limiting factor restricting the speed at which a scramjet can operate relates directly to the time it takes for the fuel and air to mix and burn. Using hydrogen as the fuel source brings this time to a minimum. Due to the low den ...

Testing of satellite navigation receivers and their associated antenna systems is a critical component of fielding new navigation equipment for the warfighter. Anechoic chambers and open-air test ranges are typically used to test these systems in benign environments and in the presence of electronic attack (EA). A need exists for an indoor, dynamic satellite constellation simulation to bridge a te ...