Award Data

GeneCapture, Inc. is proposing to develop a rapid in vitro diagnostic prototype using our patented molecular-based CAPTURE (ConfirmActive Pathogens Through Unamplified RNA Expression) assay. Based on the results and experience gained in our Phase I STTR contractHDTRA1-16C-0061: Infectious Disease Diagnostics and Differentiation of Viral vs. Bacterial Infections for Point of Care Applications, we p ...

This project is a unique metagenomic evaluation of under-studied extremophilic microbiome natural products (NPs), with the goal of discovering novel antibiotic biowarfare agent (BWA) countermeasures. A metagenomic biosynthetic gene cluster library from extremophilic sources was created, sequenced, analyzed, and exploited to produce several broad-spectrum antibiotic extracts during the Phase I effo ...

Typical procedures for respirator masks sizing and protective fit test are time-consuming and user intensive, requiring taking anthropometricmeasurements of the wearer, sampling the wearers breathing zone and the use of specialized tools and equipment. The proposed softwareapp aims to quickly, accurately and automatically perform respirator mask sizing and predict protective fit using only 2D imag ...

Aflatoxins B1 (AFB1) are fungal produced mycotoxins that are present in food supplies and are strongly associated with increased risk for thedevelopment of hepatocellular carcinoma. Currently, there are no known countermeasures to selectively mitigate AFB1 toxicity. To meet thischallenge, we successfully validated a Phase I proof-of-concept study to harness the microbiome extracts of scavenging ma ...

Interfaces on existing military chemical/biological protection garments are not designed to fully eliminate macroscopic and microscopic air gaps at folds, fabric surfaces, or hook-and-loop closures, and thus do not provide a hermetic barrier against exposure. Creare is developing hermetic garment closure systems that seal macroscopic and microscopic gaps at interfaces and closures and provide high ...

The technology pathway to transition the successful CO2 removal system into small-scale production, and address technical hurdles associated with manufacturing, is outlined in this proposal. The electrochemical CO2 removal system generates no heat as it separates CO2 from the humid breathing gas mixture. In parallel, a breath monitoring micro-sensor array to measure temperature, humidity, CO2, and ...