Award Data

PROJECT SUMMARY Sclerodermasystemic sclerosisSScis an autoimmune disease of unknown etiology that is characterized by vascular dysfunctionfibrosisand inflammationOne in three patients dies withinyears of diagnosisgiving SSc the highest case fatality rate of any systemic autoimmune diseaseA lack of biologically relevant SSc disease models has created a critical unmet need for more efficient preclin ...

The Advanced Space Suit carries consumable cooling water maintained at ambient pressure within a soft-walled, flexible reservoir. To ensure uninterrupted thermal control it is critical to monitor the volume of water remaining, but no known sensor is suitable for this task. Existing measurement techniques are unacceptably sensitive to the motion and varying geometry of the reservoir in microgravity ...

Diode-Pumped Alkali Lasers (DPALs) have great potential for high-energy lasers. Proper design of these systems is challenging because many interrelated processes impact their performance, and critical kinetic rate coefficients are not well known. In response, our team is developing a comprehensive physics-based analysis/design tool, and experimentally determining key kinetic rate coefficients. The ...

ImmuNext has defined an anti-MCT1 monoclonal antibody (mAb) that will be developed for the treatment of human autoimmune disease. The membrane monocarboxylate nutrient transporter SLC16A1 (MCT1) is a multi-pass transmembrane protein responsible for the facilitated transport of critical metabolites, including products of glycolysis: lactate, pyruvate and ketones. Our strong preliminary data support ...

NODA Telehealth system improves access to an autism diagnostic assessment by guiding families to share video clips of their child at homeso diagnostic clinicians can directly observe andtagvideo of any atypical behaviorand if warrantedrender a diagnosisThis system is evidence based and has been commercializedwith several published studies to discuss the benefitsWe now propose to improve this servi ...

PROJECT SUMMARY ABSTRACT The National Research Council recognizes that serious computer games can support new inquiry based approaches to science instructionproviding virtual laboratories or field learning experiences that overcome practical and logistical constraints to student investigationsWith the nationally recognized need to encourage and enhance education in the ScienceTechnologyEngineering ...

Mentis Sciences Inc. proposes to develop Technical Data Packages and generate Source Approval Requests for critically needed components for the Air Launched Cruise Missile engine platform, the F107, which is no longer supported by the OEM. The supply of some spare parts may be exhausted as early as Oct 2018, on a system that is scheduled to remain in service through at least 2030.Mentis will work ...

Blast induced Traumatic Brain Injury (TBI) is a major threat to the health of military personnel serving in modern theaters. As such, the biomechanical injury pathways of TBI are, and have been, the focus of many animal studies. However, differences in the experimental setups across laboratories make it difficult to draw definitive conclusions from the resulting data. A tool that can accurately es ...

TECHNICAL ABSTRACT: Ensuring the health of coastal marine ecosystems has emerged as one of the primary environmental concerns of this century. Frequent monitoring of water quality is required to establish baseline levels and enable early detection of problems. Citizen science programs have been shown to provide a highly effective method of monitoring water quality. Creare is developing an open-sou ...

TECHNICAL ABSTRACT: Commercially available unmanned aircraft systems (UASs) are not well designed to meet requirements for many atmospheric measurement applications, including deployment from ships, long endurance, and low cost. Existing multi-rotor systems suffer from limited payload and endurance. Existing fixed wing systems offer improved endurance and payload, but require significant support h ...