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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 1 - 10 of 57 results
 
  • Record 1 TO 57

  1. Phase II Clinical Trial of Lactoferrin in Asthma

    SBC: AGENNIX, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The purpose of this research is to determine the efficacy of orally administered recombinant human lactoferrin (rhLF) in Phase II clinical trials in patients with mild to moderate asthma. Asthma is one of the most prevalent chronic inflammatory diseases in the United States affecting approximately 15 percent of the population. Despite intensive research on as ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health

  2. Ultra Rapid Methods for Streamlined Tissue-to-RT-PCR

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This Phase II proposal aims to simplify, expedite, and stabilize the recovery of high quality RNA from tissue samples. In Phase I, we demonstrated the feasibility of a hands-off, closed tube tissue disruption method termed "MELT" (Multi-Enzymatic Liquefaction of Tissue). MELT enlists potent catabolic enzymes to liquefy tissue within minutes without invasive ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health

  3. Cost-Effective Manufacturing of Pharmaceutical mRNA

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The overall objective of this proposal is to develop methods for the cost-effective, large-scale synthesis (up to kilograms amounts) of capped, polyadenylated RNA. Several companies are using capped RNA to produce human vaccines against cancers and infectious diseases such as HIV and biowarfare agents. Ambion's patented mMESSAGEmMACHINE(r) kit provides high- ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health

  4. Enabling RNA Analyses from Formaldehyde-fixed Tissues

    SBC: AMBION DIAGNOSTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term objectives of this proposal are to permit the isolation of RNA from fixed and imbedded tissues for gene expression analysis. The widespread use of tissue fixation and embedding in both clinical and research settings has resulted in the accumulation of large stores of fixed and embedded tissues in medical schools, hospitals, and universities. The ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health

  5. DIMETHYLSUBERIMIDATE AS A PULPOTOMY AGENT

    SBC: Biomedical Development Corporation            Topic: N/A

    THE LONG-TERM GOAL OF THIS APPLICATION IS TO DEVELOP DIMETHYLSUBERIMIDATE (DMS) AS AN ALTERNATIVE PULP THERAPY. FORMOCRESOL, THE DRUG MOST COMMONLY USED FOR TREATMENT OF CARIOUSLY EXPOSED PULPS OF THE PRIMARY DENTITION, IS TOXIC TO THE TREATED TISSUE, INDUCES ANTIGEN FORMATION AND SUBSEQUENT CHRONIC INFLAMMATION, IS RAPIDLY DISTRIBUTED SYSTEMICALLY, AND HAS MUTAGENIC POTENTIAL. FORMOCRESOL PULPOTO ...

    SBIR Phase II 1987 Department of Health and Human Services

  6. N/A

    SBC: Biomedical Development Corporation            Topic: N/A

    N/A

    SBIR Phase II 2000 Department of Health and Human ServicesNational Institutes of Health

  7. N/A

    SBC: Biotex, Inc.            Topic: N/A

    N/A

    SBIR Phase II 2000 Department of Health and Human ServicesNational Institutes of Health

  8. Cooled Laser Delivery System: Improved Thermal Therapy

    SBC: Biotex, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The focus of this research is to continue development of a novel interstitial cooled laser delivery system for improved thermal therapy. The system is intended to find applications in the thermal destruction of cancerous tumors. Laser interstitial thermal therapy (LITT) is an ideal method for minimally invasive treatment of localized tumors, but has so far fa ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health

  9. Interactive Image Guided Closed Loop Thermal Therapy

    SBC: Biotex, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this Phase II Competing Continuation research project is to complete the Phase I clinical trial of a new magnetic resonance imaging guided minimally invasive treatment for focal brain tumors. Over the past four years, BioTex has developed the Visualase(r) thermal therapy system for treatment of localized cancers by using temperature-sensitive mag ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health

  10. Mandibular Bone transport Reconstruction Plate

    SBC: Custom Scientific            Topic: N/A

    DESCRIPTION (provided by applicant): Surgical excision of hard and soft tissues of the head and neck or high impact trauma can lead to lead to major tissue deficits. Reconstruction of the lower jaw typically involves bone, gingiva, and teeth. Current mandibular distraction devices are used in combination with reconstruction plates, but while the reconstruction plates take the contour of the jaw, t ...

    STTR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
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