Award Data

The goal of this proposal is find novel combinations of approved drugs for the treatment and/or prevention of infection with filoviruses. Ebola and Marburg viruses, the only filoviruses, cause an acute hemorrhagic fever syndrome which has a high mortality rate and poses a significant bio-terrorism threat. There are currently no therapeutic agents available to treat filovirus infections and the de ...

The objective of this research is prove the feasibility of automatically migrating radiation effects predicted in TCAD level tools to compact modeling tools. This transition will enable compact models that possess radiation effects to be quickly generated, which can then be used in circuit design activity. This "model-in-a-day" approach is a substantial improvement over the current ad hoc approach ...

Manning Applied Technology proposes to develop a handheld infrared spectrometer, ideally suited to detection of airborne chemical agents at and below permissible exposure limits. This approach offers unmatched sensitivity and specificity for detection of all types of chemical vapors. The instrument is modular, rugged, compact and highly sensitive. Volume pricing will be less than $1000 each. ...

It is proposed to formulate an equation(s) to describe the (A) evaporation and (B) death rates of aerosolized bacteria in their spent culture fluid droplets. This formulation will account for effects of atmospheric temperature, relative humidity, solar radiation, droplet solute concentration, and droplet size effects perhaps including effects of solute-particle (i.e,, bacteria) concentration and p ...

PRESHOCKED PRECONDITIONING OF TUFF MAY OCCUR IN TWO MANNERS AT THE NEVADA TEST SITE. FIRST, THE MATERIAL IS "PRESHOCKED" IN A LINEOF-SIGHT TYPE UNDERGROUND NUCLEAR TEST BY THE FIRST WAVE PASSAGE. THE SECOND MANNER MAY OCCUR AS A RESULT OF AREAL SPACE LIMITATIONS WHEN A SECOND EVENT IS SITED WITHIN A REGION OF PRESHOCKED MATERIAL. UNDER CERTAIN LOAD-UNLOADED CONDITIONS THE MATERIAL STRENGTH MAY BE ...

SHEAR DISPLACEMENT ALONG ROCK MASS DISCONTINUITIES (JOINTS) UNDER SATURATED, UNDRAINED CONDITIONS IS ONE OF THE CRITICAL FAILURE MODES FOR A DYNAMICALLY LOADED DEEP BASE STRUCTURE. THE FAILURE MODE HAS NOT BEEN EXPERIMENTALLY SIMULATED FOR DEEP BASE CONDITIONS. THE COMBINED APPLICATION OF NORMAL AND SHEAR STRESSES AT DYNAMIC RATES, WITHOUT PORE PRESSURE DRAINAGE, IS LIKELY TO PRODUCE HIGH PORE PRE ...