Award Data

The goal of this proposal is find novel combinations of approved drugs for the treatment and/or prevention of infection with filoviruses. Ebola and Marburg viruses, the only filoviruses, cause an acute hemorrhagic fever syndrome which has a high mortality rate and poses a significant bio-terrorism threat. There are currently no therapeutic agents available to treat filovirus infections and the de ...

78188S Ultra-Supercritical (USC) coal-fired power plants are being designed to meet the Vision 21 goals of fuel efficiency and environmental emission standards. The material systems for these plants will be required to limit degradation occuring from corrosion at elevated temperatures. Due to higher operational temperatures in USC plants (up to 750 C), the environments encountered in these plant ...

79108S DNA and protein chip microarray technology relies upon fluorescent labels to visualize DNA hybridization and antigen/antibody binding. A recent breakthrough at Oak Ridge National Laboratory has demonstrated the possibility of label-free detection of DNA hybridization using a microcantilever as the "chip reader." A label-free analyte sensing system would: (1) solve the problem with photob ...

79798B The design of a high-resolution fragment separator for a facility such as the Rare Isotopes Accelerator (RIA) requires the use of magnets that offer special combinations of magnetic field, aperture, high order correction, and radiation resistance. Although optical designers can optimize the layout of the magnets and their characteristics, a complete optimization must account for other aspe ...

78617S The DOE is interested in reducing the emission of particulate matter in gaseous effluent from both thermal and non-thermal treatment facilities, including coal-fired power plants, incinerators, metals manufacturing, chemical plants, and nuclear treatment facilities. Progress in this area will require the development of instruments to monitor the mass and composition these particulates. T ...

Manning Applied Technology proposes to develop a handheld infrared spectrometer, ideally suited to detection of airborne chemical agents at and below permissible exposure limits. This approach offers unmatched sensitivity and specificity for detection of all types of chemical vapors. The instrument is modular, rugged, compact and highly sensitive. Volume pricing will be less than $1000 each. ...

78845S The Department of Energy desires to increase fuel efficiency by reducing vehicle weight. Carbon fiber composites offer one promising way to do this, but difficulties in building economical, consistent, high quality preforms has limited the introduction of this material. This project will to adapt a well established pulp molding technology to produce carbon fiber preforms for lightweight ...

79221 Bright muon beams are required for muon colliders, neutrino factories, amd intense muon sources. The muons must be produced by smashing high energy protons into a target to generate pions that then decay into a diffuse cloud of muons. The muons must be: (1) captured in strong magnetic fields, (2) bunched by strong RF electric fields, and (3) precooled by passing the beam through a low-Z e ...

79264 In the proposed muon collider, luminosity depends on the number of muons in the storage ring and on the transverse size of the beams in collision. However, an adequate luminosity requires large muon intensities because, as presently envisioned, the method to cool the beam, ionization cooling, does not cool the beam sufficiently to provide adequate luminosity without large muon intensities. ...

The overall objective of this proposal is to demonstrated that imidazenil is a more potent and safer protective agent than diazepam against chemical warfare nerve agent (CWNA)-induced seizure/status epilepticus, neuropathology, and neurobehavioral deficits. Thus we will compare the dose-dependent efficacy of imidazenil or diazepam administered alone and in combination with levetiracetam in protect ...