Award Data

RESEARCH AND DEVELOPMENT WILL BE CARRIED OUT TO PROVIDE PROTOTYPE, ACTIVELY CONTROLLED GAS BEARINGS FOR PRECISION MOVEMENT IN INSTRUMENTS AND MACHINE TOOLS. THIS WILL DRAW UPON PRELIMINARY WORK ON (1) FABRICATION, (2) DYNAMIC ANALYSIS OF THE BEARING AND SUPPORTED MASS, (3) PIEZOELECTRIC VALVING AND PIEZOELECTRIC DISPLACEMENT OF THE BEARING SURFACE, AND (4) THE ADAPTATION OF A MICROPROCESSOR TO SER ...

AN ICE NUCLEATION GENE FROM PSEUDOMONAS SYRINGAE IS CLONED IN E. COLI AND ANALYSED BY DIRECTED MUTAGENESIS. PRECISE DUPLICATIONS AND DELETIONS OF REPETITIVE DOMAINS ARE GENERATED; NON-REPETITIVE DOMAINS ARE TARGETED FOR PARTIAL DELETION. THE RESULTING CONSTRUCTS ARE ANALYSED FOR THEIR EFFECTS ON THE TEMPERATURE SPECTRUM OF NUCLEATION FREQUENCY AND FOR THE ABILITY OF THEIR GENE PRODUCTS TO BE INCOR ...

THE SUCCESSFUL APPLICATION OF BIOLOGICAL CONTROL AGENTS TO FIELD DISEASE CONTROL PROBLEMS IS LIMITED TO A FEW RESTRICTED EXAMPLES. ONE BASIC LIMITATION IN OUR KNOWLEDGE OF THE MECHANISMS OF BIOLOGICAL CONTROL WITH RHIZOSPHERE COLONIZING BACTERIA (RHIZOBACTERIA) HAS BEEN THE LACK OF RIGOROUS TESTING OF THE ROLE OF ANTIBIOTICS PRODUCED DURING COLONIZATION. IN THIS RESEARCH, WE PROPOSE TO EVALUATE TH ...

A LIMITATION TO THE USE OF PLANT SOMATIC EMPBYOS AS A PROPAGATION TOOL IS THE GERMINATION FREQUENCY OF EMBRYOS INTO PLANTLETS. FOR NON-ENDOSPERMOUS EMBRYOS, SUCH AS ALFALFA OR LETTUCE, THE MAJOR SEED STORAGE PROTEINS ACCUMULATE IN THE COTYLEDON AND HYPOCOTYL AXIS OF ZYGOTIC EMBRYO PROPER. SOMATIC EMBRYO DEVELOPMENT IN ALFALFA IS ACCOMPANIED BY EXPRESSION OF SEED STORAGE PROTEIN. THE GREATEST AMOUN ...

THE RESEARCH PROPOSED IN THIS PHASE I EFFORT WILL EVALUATE THE FEASIBILITY OF DEVELOPING A QUANTITATIVE LASER IONIZATION MASS SPECTROMETRY (LIMS) TECHNIQUE FOR THE MICROANALYTICAL CHARACTERIZATION OF INSULATING MATERIALS. THE DEVELOPMENT OF THIS QUANTITATIVE CAPABILITY COULD HAVE BOTH SIGNIFICANT SCIENTIFIC AND ECONOMIC IMPACT SINCE IT COULD PROVIDE (FOR THE FIRST TIME) A RAPID MICROANALYTICAL TEC ...

THE RECENT DEVELOPMENT OF MOLECULAR BIOLOGY, PARTICULARLY INTHE FIELD OF RECOMBINANT DNA TECHNOLOGY, GIVES BIRTH TO A NEW ERA IN MEDICAL THERAPEUTICS AND DIAGNOSTICS USING PRODUCTS FROM MAMMALIAN CELL CULTURE. FOR EFFECTIVE RESEARCH AND CLINICAL USE, THESE PRODUCTS NEED TO BE MANUFACTURED IN LARGE QUANTITIES AND AT A TOLERABLE COST. TODAY PRODUCTION COSTS ARE VERY HIGH. THIS PROPOSAL IS PARTOF AN ...

GENES SPECIFYING CHITINASE FROM SERRATIA MARCESCENS HAVE BEEN ISOLATED AND CHARACTERIZED. EVIDENCE THAT THIS PRODUCTIS INVOLVED IN THE CONTROL, BY THIS ORGANISM, OF CERTAIN FUNGAL DISEASES IS PROVIDED. THIS PROPOSAL DESCRIBES EXPERIMENTS IN WHICH THE REGULATORY ELEMENTS OF A PLANT GENESPECIFYING THE APOPROTEIN OF THE LIGHT HARVESTING COMPLEX ARE FUSED TO THE CODING PORTION OF A SERRATIA MARCESCENS ...

THIS PHASE I EFFORT WILL APPLY THEORETICAL METHODS BASED PRINCIPALLY ON CAGNIARD'S FORMALISM (PREVIOUSLY INCORPORATED BY US INTO OUR POWERFUL SWREF CODE), TO THE PROPAGATION AND FOCUSING, IN BOTH REFLECTIVE AND PHASED-ARRAY EQUIPMENT, OF SHOCK-WAVES PRODUCED BY UNDERWATER SPARKS. THE OBJECTIVE IS TO INVESTIGATE AND PROVIDE DESIGN DATA FOR LITHOTRIPSY EQUIPMENT IN WHICH FOCUSED SHOCK WAVES ARE USED ...

THE PURPOSE OF THE PROPOSED EXPERIMENT IS TO CONDUCT AN EVALUATION OF TRANSITION RADIATION FOR THE NON-INVASIVE ASSESSMENT OF CORONARY ARTERY DISEASE IN HUMANS. THE HIGH BRIGHTNESS AND LASER-LIKE COLLIMATION OF TRANSITION RADIATION, MAKE IT AN IDEAL SOURCE OF X-RAYS FOR MEDICAL APPLICATIONS. RECENT EXPERIMENTS USING SYNCHROTRON EMISSION AS A SOURCE OF X-RAYS, COUPLED WITH IN VIVO DETECTION OF IODI ...

CONVENTIONAL ROCK CORE DRILLING AT GREAT DEPTHS IS EXTREMELY EXPENSIVE AND TIME CONSUMING. ITS MAJOR DRAWBACK IS THE REQUIRED LENGTH OF DRILL PIPE. THE SUSPENSION CORE DRILL IS SUPPORTED BY CONTINUOUS FLEXIBLE LEADS HELD ON ONE OR MORE HIGH-SPEED REELS. WITHDRAWALS AND REPLACEMENT TIMES CAN BE REDUCED BY AN ORDER-OF-MAGNITUDE. COMMERCIAL USES INCLUDE STANDARD CORING APPLICATIONS AS WELL AS INTERMI ...