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The Award database is continually updated throughout the year. As a result, data for FY21 is not expected to be complete until September, 2022.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. A Miniature Autoinjector for Multicomponent Drugs and Vaccines

    SBC: CREARE LLC            Topic: CBD13106

    Chemical, biological, or toxin attacks in military and civilian settings are a serious and growing concern. Standard first aid for exposure to some chemical warfare agents and toxins includes the immediate administration of relevant antidotes using an autoinjector. When an attack occurs, pre-filled autoinjectors must be immediately available and thus highly portable, and they must be suitable fo ...

    SBIR Phase II 2014 Department of DefenseOffice for Chemical and Biological Defense
  2. An automated, high throughput, resin-free device for large scale protein purification

    SBC: CFD Research Corporation            Topic: CBD12102

    Protein manufacturing is of paramount importance to chemical and biological defense applications. Existing protein purification methods primarily rely on synthetic-resin based chromatography, which is time-consuming, labor-intensive, expensive, and consequently, ill-suited for developing rapid countermeasures to chemical and biological threats. To overcome these limitations, the overall goal of th ...

    SBIR Phase II 2014 Department of DefenseOffice for Chemical and Biological Defense
  3. A Novel, Aerodynamics-augmented Continuous Ionization System for Electrostatic Collection of Bioaerosols

    SBC: CFD Research Corporation            Topic: CBD12107

    Safe and efficient ionization and filtration technology compatible to biodefense applications is of paramount importance. Current ionization methods are energy-intensive, costly, prone to ozone generation, or inefficient, and consequently ill-suited for building protection applications. To overcome these limitations, we propose to develop and demonstrate a novel bioaerosol ionization and collectio ...

    SBIR Phase II 2014 Department of DefenseOffice for Chemical and Biological Defense
  4. A Novel Microfludic Device for Drug Toxicity Studies

    SBC: CFD Research Corporation            Topic: CBD10103

    Current drug discovery and development efforts are severely limited by expensive animal trials and oversimplified in vitro models. Results obtained from in vitro models are not predictive of in vivo toxicity owing to significant difference from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device that reproduces the physiological ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  5. Hermetic Seals for Chemical/Biological Protective Garments

    SBC: CREARE LLC            Topic: CBD13109

    Interfaces on existing military chemical/biological protection garments are not designed to fully eliminate macroscopic and microscopic air gaps at folds, fabric surfaces, or hook-and-loop closures, and thus do not provide a hermetic barrier against exposure. Creare proposes to develop a hermetic garment closure system that seals macroscopic and microscopic gaps at interfaces and closures and pro ...

    SBIR Phase II 2014 Department of DefenseOffice for Chemical and Biological Defense
  6. Keratin Biomaterials for Cranio-facial Tissue Engineering

    SBC: Keranetics, LLC            Topic: OSD09H10

    The majority of personnel injured in OIF/OEF have suffered blast injuries from IEDs. Blasts often cause cranio-facial trauma that is difficult to repair surgically. The current standard of care involves the placement of fixation devices and off label use of growth factor carriers. These strategies often require multiple surgical interventions creating a significant need for better technologies ...

    SBIR Phase II 2011 Department of DefenseDefense Health Agency
  7. Light-weight, Low-volume, High Oxygen Storage Density Material for Self-Contained Breathing Apparatus

    SBC: MAINSTREAM ENGINEERING CORPORATION            Topic: CBD12105

    This proposal outlines Mainstreams successful Phase I feasibility demonstration related to the fabrication of hierarchical hybrid nanomaterials for oxygen storage vessels. These vessels exceed the volumetric and gravimetric storage capacity of an oxygen cylinder by 245% and 170%, respectively. Included in these storage density values is a solid-state oxygen regulation system that also enables comp ...

    SBIR Phase II 2014 Department of DefenseOffice for Chemical and Biological Defense
  8. Microfluidic High-throughput Platform for Determining Kinetic Constants of Enzyme Variants

    SBC: CFD Research Corporation            Topic: CBD10107

    Current high-throughput platforms rely on labeled substrates that produce detectable spectroscopic signals upon reaction for monitoring enzyme catalytic activity. Add to that the high price tag for these instruments, ranging from several hundred thousand to millions of dollars, and there is a clear need for alternate solutions for a label-free, low-cost, high-throughput enzyme screening platform. ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  9. Multisegmental Sensor Integration for Balance Control

    SBC: Engineering Acoustics Incorporated            Topic: DHP12008

    Recent advances in Micro-Electrical-Mechanical Systems (MEMS) have made accessible a variety of extremely small, rugged, reliable, low power consumption, and inexpensive AHRS sensors for motion capture. A collection of these devices should be capable of providing similar proprioceptive information that the distributed biological sensors of the human body provide the brain to carry out complex mob ...

    SBIR Phase II 2014 Department of DefenseDefense Health Agency
  10. Synergistic and Smart Micro-Controls for Enhanced SCBA Equipment

    SBC: MAINSTREAM ENGINEERING CORPORATION            Topic: CBD14103

    This proposal outlines the successful demonstration of electrochemical CO2 removal that generates virtually no heat, from a humid breathing gas mixture. Mainstream evaluated micro-sensors for monitoring temperature, humidity, CO2, and O2 for breath monitoring for the self-contained breathing apparatus (SCBA). Advanced CO2 separating technology combined with micro-sensors and controls allows for op ...

    SBIR Phase II 2014 Department of DefenseOffice for Chemical and Biological Defense
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