Award Data

Sequencing the human genome has uncovered numerous putative novel targets for which 3D structures are not available and which have no known inhibitors. We proposed a system to use computational methodologies to generate 3D molecular models of target proteins, and to use these models to design novel chemical inhibitors. Currently, the system is capable of accurately folding a target's amino acid se ...

Lithium-based batteries promise excellent performance, although they require careful management to avoid personnel injury and equipment damage. Consequently, there is extreme interest in developing accurate Battery Management Systems (BMS) to take advantage of the positive attributes of lithium-based chemistries without sacrificing flexibility and safety. However, the lack of proper BMS standardiz ...

Current drug discovery and development efforts are severely limited by expensive animal trials and oversimplified in vitro models. Results obtained from in vitro models are not predictive of in vivo toxicity owing to significant difference from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device that reproduces the physiological ...

LIT Proposed development of a Secure Test/Programming Interface (STPI) that provides both Access Control and Tamper Detection. Phase I achievements include: Probe/Connection Detect Low Component Impact Through-the-System Protection Around-the-System Protection Layered Authentication In Phase II, LIT will advance the STPI AT technology by developing STPI product concepts and by demonstrating t ...

Accurate estimations of the height and velocity of precision airdrop systems are required to control final deceleration maneuvers. Airdrop systems have a limited deceleration window, so robust and reliable estimations are required. Radar, sodar, and lidar sensors have been evaluated for this role with varying degrees of success. Foliage and vegetation prove troubling for many of the sensors. H ...

The development of carbon-based nano-additive bound polymers with enhanced adsorption capacity and reactivity for the neutralization of chemical and biological warfare agents could cause substantial saving of life during CBWA threats. In the Phase I pr

Protective garments that isolate a dismounted soldier from the environment can also build up excessive internal heat and humidity, impairing performance and possibly leading to heat casualties. We propose to develop an innovative microclimate control system that will maintain a cool, dry environment inside protective garments. There are two key innovations: (1) a novel cooling process that enables ...

Fully automated approaches to target detection are efficient at processing large amounts of data but often rely heavily on the training data and the model employed. Training data and modeling assumptions can be violated in the operational environments where the algorithms are applied. Alternatively, human manual target detection is accurate and adaptable due to the human ability to interpret data ...

The U. S. Army recognizes the need for a safe, portable battery that can be used as a charger to recharge small lithium-ion batteries such as LI7 land warrior battery. The successful completion of Phase I project demonstrates the feasibility of defining the design and dimension of such charger battery leads to the development of prototype charger. A novel electrochemical couple will be used fo ...

SRD is proposing to develop a next-generation chemical permeation hybrid sensor module based on a semiconducting metal oxide (SMO) and polymer-coated surface acoustic wave (P-SAW) sensor array for real-time permeation testing of chemical agent protective