Award Data

Current drug discovery and development efforts are severely limited by expensive animal trials and oversimplified in vitro models. Results obtained from in vitro models are not predictive of in vivo toxicity owing to significant difference from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device that reproduces the physiological ...

The development of carbon-based nano-additive bound polymers with enhanced adsorption capacity and reactivity for the neutralization of chemical and biological warfare agents could cause substantial saving of life during CBWA threats. In the Phase I pr

information) During Phase I the Torch Technologies developed, demonstrated, and assessed the feasibility of an innovative, real-time multi-layered CW sensor data fusion network capability supporting advanced standoff detection and early warning against CB threats. Torch merged two significant technologies that we developed for the Department of Defense: 1) the ACRES CW multi-sensor data fusion t ...

The majority of personnel injured in OIF/OEF have suffered blast injuries from IEDs. Blasts often cause cranio-facial trauma that is difficult to repair surgically. The current standard of care involves the placement of fixation devices and off label use of growth factor carriers. These strategies often require multiple surgical interventions creating a significant need for better technologies ...

Current high-throughput platforms rely on labeled substrates that produce detectable spectroscopic signals upon reaction for monitoring enzyme catalytic activity. Add to that the high price tag for these instruments, ranging from several hundred thousand to millions of dollars, and there is a clear need for alternate solutions for a label-free, low-cost, high-throughput enzyme screening platform. ...

This Phase II SBIR proposal is for the development of a miniaturized real-time visible/UV spectrometer prototype based on micro-opto-electro-mechanical systems (MOEMS) technology. Use of MOEMS technology enables orders of magnitude reductions in size, we

Our objective is to develop a novel micropower source to be integrated with a microsensor, and communication chip on an insect, delivering a state-of-the-art unmanned chemical detection device. The biological fuel cell (Bio-FC) power source will leverage ongoing research at CFDRC and provide a compact/lightweight power supply for mounting on numerous types of insects and producing necessary power ...

In the wake of the September 11th attacks and subsequent Anthrax scares, researchers worldwide are working to expand our ability to rapidly assess what poses a terrorism threat to the public. The rapid detection of specific pathogens is required for biod