Award Data

Organophosphorus chemical warfare nerve agents (OP-CWA) are attractive to terrorist groups and rogue states as an inexpensive and accessible technology for chemical warfare. OP-CWA and organophosphate pesticides cause severe neurological symptoms and death by inhibiting the enzyme acetylcholinesterase (AChE); the resulting excess acetylcholine accumulates and overstimulates the human or animal bo ...

Current drug discovery and development efforts are severely limited by expensive animal trials and oversimplified in vitro models. Results obtained from in vitro models are not predictive of in vivo toxicity owing to significant difference from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device that reproduces the physiological ...

In this Phase II SBIR project for the Army CBD, Torch Technologies of Huntsville, AL, will develop and demonstrate a fully operational prototype of its Advanced Chemical Release Evaluation System for fusing measurements of the concentration of clouds resulting from chemical releases. The ability to evaluate the performance of a stand-off detector during development depends on the ability to accura ...

Manning Applied Technology proposes development of the MP-100 handheld FT-infrared photoacoustic chemical agent detector, following a highly successful Phase I effort. Chemical attacks and accidents can be mitigated partially by cost-effective sensors. High priority programs will benefit from a sensor compliant to Joint Warning & Reporting Network (JWARN) standards. The device is ideally suited to ...

THE PURPOSE OF THIS RESEARCH IS TO STUDY THE FEASIBILITY OF QUANTIFYING THE EFFECTS OF IREASED AUTOMATION ON THE WORKLOAD AND PERFORMANCE OF THE FEDERAL AVIATION ADMINISTRA-TION'S AIR TRAFFIC CONTROLLER. IN PHASE I, RESEARCH WILL FOCUS ON ADAPTRING OUR CURRENT HUMAN PERFORMANCE MODEL TO REPRESENT THE JOB CHARACTERISTICS OR ATTRIBUTES THAT WILL DETERMINE LEVELS OF WORKLOAD AND PERFORMANCE IN THE AD ...

Current high-throughput platforms rely on labeled substrates that produce detectable spectroscopic signals upon reaction for monitoring enzyme catalytic activity. Add to that the high price tag for these instruments, ranging from several hundred thousand to millions of dollars, and there is a clear need for alternate solutions for a label-free, low-cost, high-throughput enzyme screening platform. ...

Defense against chemical weapons is a critical DoD requirement. An effective defense requires the development of a combination of unique clothing systems that provide a physical barrier to toxic vapors, liquids, and aerosols, as well as a system to detect chemical threats. Protective clothing and detection systems currently exist, but ideally the detection equipment should be miniaturized and int ...

THE RECOGNIZED LOW LEVEL WIND SHEAR PHENOMENON KNOWN AS A MICROBURST POSES A SERIOUS AIR SAFETY THREAT TO COMMERCIAL AVIATION WHILE IN A LANDING OR POSES A SERIOUS COMMERCIAL AVIATION WHILE IN A LANDING OR TAKEOFF PATTERN. THIS LOW LEVEL WIND SHEAR HAS BEEN DEMONSTRATED TO DE A THIS LOW LEVEL WIND SHEAR HAS BEEN DEMONSTRATED TO BE A MAJOR CONTRIBUTING FACTOR TO SEVERAL CRASHES OF COMMERCIAL AIRLIN ...

During Phase I, IEM developed a proof of concept for a Smart Grade Crossing Monitor (SGCM) using multispectral imaging technology for enhanced monitoring of highway rail grade crossings to improve safety by providing warnings of significant objects present in the crossing. The Phase I work conclusively demonstrated that multispectral imaging is clearly superior to visible or infrared spectrum imag ...

As stated in the solicitation, the pavement infrastructure in the US covers a large surface area and requires intensive energy and natural resources. In addition, the surface of the pavement is typically impermeable, causing negative consequences. Vehicles that travel over these pavements are also resource intensive. Solar Roadways Incorporated envisions replacing current asphalt surfaces with m ...