Award Data

The proposed low-SWaP PAPR technology improves the convenience, comfort, and protection level for respirators used in low-threat hazardous environments. Creare’s PAPR technology will be applicable to a variety of respiratory protection needs, including emergency escape, laboratory and field work in low-hazard conditions, and some combat and combat support activities. The PAPR will improve user f ...

Current drug discovery and development efforts are severely limited by expensive animal trials and oversimplified in vitro models. Results obtained from in vitro models are not predictive of in vivo toxicity owing to significant difference from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device that reproduces the physiological ...

The skin is the first line of defense against chemical warfare agents including nerve agents and toxic industrial chemicals, providing a possible barrier or delay to systemic distribution. Some chemicals also can act directly on the skin including the vesicants sulfur mustard and lewisite. Early and rapid skin decontamination is extremely important following exposure to CWAs and TICs because it de ...

Interfaces on existing military chemical/biological protection garments are not designed to fully eliminate macroscopic and microscopic air gaps at folds, fabric surfaces, or hook-and-loop closures, and thus do not provide a hermetic barrier against exposure. Creare is developing hermetic garment closure systems that seal macroscopic and microscopic gaps at interfaces and closures and provide high ...

GeneCapture, Inc. is proposing to develop a rapid in vitro diagnostic prototype using our patented molecular-based CAPTURE (ConfirmActive Pathogens Through Unamplified RNA Expression) assay. Based on the results and experience gained in our Phase I STTR contractHDTRA1-16C-0061: Infectious Disease Diagnostics and Differentiation of Viral vs. Bacterial Infections for Point of Care Applications, we p ...

Current high-throughput platforms rely on labeled substrates that produce detectable spectroscopic signals upon reaction for monitoring enzyme catalytic activity. Add to that the high price tag for these instruments, ranging from several hundred thousand to millions of dollars, and there is a clear need for alternate solutions for a label-free, low-cost, high-throughput enzyme screening platform. ...

In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens, whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial and alphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable an ...