Award Data

Currently, no commercial products exist for the repair of large injuries to muscle, particularly volumetric muscle loss (VML). In Phase I of this project, data demonstrated that keratin biomaterials can provide temporal release of growth factors while maintaining cell viability in vitro and in vivo. In Phase II, the biomaterial formulation was optimized for spatio-temporal delivery of cells and gr ...

Current methods for stem cell isolation are time-consuming, costly, and labor-intensive, and ill-suited for point of care applications. To overcome these limitations, we propose to develop and demonstrate a high-throughput, non-invasive, microfluidic stem cell analyzer to enable a rapid isolation of high-quality stem cell products from clinically relevant samples. Our technology enables significan ...

The vast majority of injuries in recent military conflicts have been inflicted by improvised explosive devices (IEDs) causing brain, extremities and genital-urinary injuries. Advanced computational models of IED blast physics and human body injury biomech

The overall objective of the proposed project is to develop new injury criteria, model based risk assessment methodology, and a software tool to assess neck injury risk from head supported mass (HSM) loading. Based on the foundation of Phase I feasibility studies, the proposed Phase II work will focus on model enhancement, extension and validation, risk assessment, and software integration and tes ...

Burn injuries, particularly those to the face, present a number of functional and psychological challenges that arise from scarring and related contracture. A major goal of trauma and burn surgeons is to prevent scarring and improve grafting technologies given the complexity of facial topography. This project seeks to optimize and finalize a prototype of a 3D printed keratin facemask capable of ...

Complete human anatomy avatars have a broad role in advanced training environments, performance-related physiological modeling, and simulations for the purpose of designing protective armor. The overall goal of this project is to design and develop computer software and data structures for adding articulated joints and natural motions to USARIEMs static finite element avatars and to create a graph ...

The objective of this project is to develop, produce, and commercialize a liquid-tight, field-applicable, ocular patch for wound stabilization and treatment of the eye following a war-related injury to the ocular surface. The patch consists of a curved flexible silicone membrane (similar in size and shape to a contact lens) which has had (1) a novel bio-adhesive

Musculoskeletal injury among military personnel is an under-recognized problem where shoulder injuries are significant and result in inflammation and pain from overuse, joint derangement, sprain/stain/rupture, and dislocation. Health hazard assessment is essential to ensure that fielded equipment and occupational duties do not exceed human capabilities over short and long term exposures. Hazard ...

The skin is the first line of defense against chemical warfare agents including nerve agents and toxic industrial chemicals, providing a possible barrier or delay to systemic distribution. Some chemicals also can act directly on the skin including the vesicants sulfur mustard and lewisite. Early and rapid skin decontamination is extremely important following exposure to CWAs and TICs because it de ...

The current methodology for testing the penetration resistance of textile materials to various chemical agents has a number of drawbacks, including significant uncertainties in the resulting data, inefficiency and expense, risk to test personnel, and limited range of test conditions. The objective of the proposed work is to apply unique computer models for textiles with accompanying experimental ...