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The Award database is continually updated throughout the year. As a result, data for FY21 is not expected to be complete until September, 2022.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. BioSphincter to Treat Fecal Incontinence. Phase 1/2 Clinical Trial. SBIR Phase IIB

    SBC: CELLF-BIO, LLC            Topic: 300

    Project Summary/Abstract:Fecal incontinence (FI), the involuntary soiling of various amounts of liquid and solid stool, is often devastating from a social, psychological, and hygiene perspective. Men and women suffer from FI equally with a range of 2 - 6% in people aged 20 - 30 years. The prevalence increases to over 15% in people older than 70 years1. FI may result from an isolated or combined lo ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Administrative Supplement for the Evaluation of the novel, uni-directional, Pd-103 CivaSheet for Lung Cancer

    SBC: CivaTech Oncology Inc.            Topic: NCI

    Parent Award: R44CA217587 Clinical Evaluation of the novel, Uni-directional Pd-103 CivaSheet for Lung Cancers CivaTech Oncology’s mission is to provide improved radiation therapy directly to localized tumors. The Company has developed a novel, polymer-encapsulated, membrane-like radiation source that emits radiation on only one side of the device – CivaSheet®. This directional source is compa ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Point-of-care device to identify patients at risk for preeclampsia

    SBC: AFFINERGY, LLC            Topic: N

    Although international trends for maternal mortality have shown an overall decline, maternal mortality rates in the United States have increased by andgt;25% since 2000. One of the leading causes for this increase is preeclampsia, a complication of pregnancy characterized by elevated blood pressure, proteinuria, and endothelial dysfunction involving multiple organ systems. Worldwide, preeclampsia ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Living with CKD: An E-Learning Platform for Adolescents with CKD about the Disease and its Management

    SBC: 3-C Institute for Social Development, Inc.            Topic: 300

    Abstract Chronic kidney disease (CKD) is a progressive condition, characterized by an irreversible deterioration of renal function that gradually progresses to end-stage renal disease, requiring dialysis or kidney transplant. CKD and its co-morbidities (e.g., hypertension, anemia, acidosis, and metabolic bone disease) require strict treatment adherence to halt progression and improve outcomes. Unf ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Targeting leukocyte metabolism to treat human autoimmune disease

    SBC: Immunext, Inc.            Topic: R

    ImmuNext has defined an anti-MCT1 monoclonal antibody (mAb) that will be developed for the treatment of human autoimmune disease. The membrane monocarboxylate nutrient transporter SLC16A1 (MCT1) is a multi-pass transmembrane protein responsible for the facilitated transport of critical metabolites, including products of glycolysis: lactate, pyruvate and ketones. Our strong preliminary data support ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. CometChip: Development of a high throughput DNA damage assay in hepatocytes

    SBC: Integrated Laboratory Systems, LLC            Topic: NIEHS

    An estimated 10,000 animals are used in toxicology safety assessments to meet all regulatory requirements with testing spanning 5 to 10 yrs and exceeding $10 million dollars. There is a critical need to reduce reliance on animal testing and to develop highly predictive human-based biological models for safety assessments. Replacement of traditional animal toxicity tests for toxicology safety asses ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. An Integrative Approach to Control Group Creation for Prevention Research

    SBC: Prevention Strategies, LLC            Topic: 550

    PROJECT ABSTRACTThe goal of this Phase II SBIR project is to develop a method for creating algorithmically generated control groupsvirtual controlsThese will be composed of synthetic cases that have two characteristicspretest similarity to whatever prevention treatment group may present itself andpatterns of change over time that closely mimic the normal course of alcohol and drug use developmentT ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. A nucleosome sliding assay platform to screen inhibitors of SWI/SNF chromatin remodeling complexes

    SBC: Epicypher, Inc.            Topic: 400

    PROJECT SUMMARYNearlyof all cancers contain mutations in subunits from the SWI SNF family of NucleosomeNucremodeling complexesThe SWI SNF family regulates local genome access by pumping DNA around histone octamersthusslidingor remodeling Nucs within chromatinRecurrent somatic mutations in SWI SNF subunits are observed in multiple cancerssupporting a driver role in tumorigenesisThe mutated complexe ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Comprehensive, Near Patient Assessment of Severe Hypoglycemia in Newborns Using Low Blood Volume

    SBC: Baebies, Inc.            Topic: NICHD

    Hypoglycemia is the most common metabolic disorder in newborns and places the neonate at increased risk of seizures and permanent brain injuryThe etiology of severe neonatal hypoglycemiawhich affects aroundnewborns each year in the U Sis complexwith underlying causes including hyperinsulinismcortisol and or growth hormoneGHdeficienciesand defects in glycogen metabolismComprehensive evaluation of t ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. A preclinical multi-modal system for dynamic noninvasive assessment of liver disease

    SBC: Sonovol, Inc.            Topic: NIDDK

    Abstract Chronic liver diseaseCLDaffects millions of people in America every yearand annually kills tens of thousands of these patientsDespite very active research effortsthere still have been no specific antifibrotic drugs approved by the FDAThe liver disease and drug development communities do not currently have wellvalidatedlow costeasy to usenoninvasive tools for studying the progression of li ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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