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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Improving the Host Response to Implantable Glucose Sensors via Nitric Oxide Release

    SBC: CLINICAL SENSORS, INC.            Topic: 200

    DESCRIPTION provided by applicant Diabetes mellitus is a metabolic disorder afflicting more than million Americans This disease manifests itself with abnormal blood glucose levels that lead to other significant health conditions including kidney failure nerve damage blindness heart attack and stroke For more than million diabetics using insulin to control hyperglycemia frequent moni ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Novel Biguanides to Treat Type 2 Diabetes

    SBC: NOVATARG, INC.            Topic: 200

    DESCRIPTION provided by applicant The present Phase SBIR application builds on the previous Phase SBIR award to identify a markedly improved biguanide to replace metformin in the treatment of T D Over new biguanides were synthesized in the Phase work and analyzed for their ability to produce metformin like activity in cells and animal models but at a much lower effective concentratio ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Intrasurgical Optical Coherence Tomography

    SBC: BIOPTIGEN, INC.            Topic: N

    DESCRIPTION provided by applicant Each year over million ophthalmic surgeries are performed worldwide Indications for ophthalmic surgery include potentially blinding diseases such as cataracts diabetic retinopathy macular disease and retinal detachment Surgeons performing these delicate procedures are challenged by the translucent nature of tissues in the eye making it nearly impossi ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Integrated Systems for the Analysis of Circulating Multiple Myeloma Cells (CMMCs)

    SBC: BIOFLUIDICA, INC.            Topic: 102

    DESCRIPTION provided by applicant Multiple myeloma MM is a plasma cell malignancy and comprises about of malignant tumors and of all hematopoietic neoplasms According to the American Cancer Society in an estimated new cases were diagnosed in the U S with the estimated deaths being Monoclonal gammopathy of undetermined significance MGUS is associated with a p ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Novel and Kidney Selective AMPK Activators to Treat Polycystic Kidney Disease

    SBC: NOVATARG, INC.            Topic: 400

    DESCRIPTION provided by applicant Autosomal dominant polycystic kidney disease ADPKD is characterized by the presence of innumerous fluid filled cysts that progressively enlarge leading nephron loss and the progressive decline in renal function Aberrant proliferation of the cyst lining epithelial cells and the accumulation of fluid within the cysts du to Cl dependent fluid secretion are res ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Therapy of transplantation-induced oxidative injury using polymeric antioxidants

    SBC: CELDARA MEDICAL, LLC            Topic: 400

    DESCRIPTION provided by applicant Ischemia reperfusion I R injury during renal transplantation surgery is responsible for oxidative stresses which result in immune activation and graft rejection We are developing an antioxidative therapy that we have already shown to be highly efficacious in ameliorating damage from oxidative stress in various in vitro models as well as I R models of kidney ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Assay Development for Measuring Chemical Effects on the Epigenome in Stem Cells

    SBC: Integrated Laboratory Systems, LLC            Topic: 113

    DESCRIPTION provided by applicant This proposed project is in response to the need for more extensive toxicological evaluation of environmental chemicals and for better predictive models to assess associated risks of chemical exposure to humans There is also need for innovative methods for evaluating the effects of chemicals on pluripotent stem cells and the differentiation process Maintenan ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  8. A crosslinked cartilage-derived matrix for cartilage tissue engineering

    SBC: Cytex Therapeutics, Inc.            Topic: NIAMS

    DESCRIPTION provided by applicant The overall goal of the present study is to resurface a diseased femoral condyle in an ovine model of unicompartmental osteoarthritis OA For patients suffering from unicompartmental OA of the knee unicondylar knee arthroplasty UKA is an available first line treatment option that provides many potential advantages over more common total knee replacement p ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Web-based Tool for the Dissemination of Evidence-based Interventions for ATOD Prevention

    SBC: 3-C Institute for Social Development, Inc.            Topic: R44

    DESCRIPTION provided by applicant Over the past several decades a large number of evidence based treatment programs for alcohol tobacco and other drug ATOD use in youth have been rigorously tested and shown to be efficacious Nevertheless evidence based ATOD programs EBPs are rarely adopted in everyday practice are seldom implemented with strong fidelity and often fail to be sustained ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Optical imaging for radiation therapy dose verification on patients

    SBC: DoseOptics LLC            Topic: 102

    DESCRIPTION provided by applicant For the first time it is possible to directly visualize a radiation beam incident upon a patientandapos s tissue in real time using Cerenkov emission imaging This imaging could transform the ease for verifying delivery in radiation oncology and allow on the fly reporting recording and correction of replanning needs or delivery errors In a field wher there ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
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