Award Data

In Operation Iraqi Freedom (OIF) 61% of soldiers injured in explosion blast events experienced Traumatic Brain Injury (TBI). The current incomplete understanding of TBI mechanisms limits the development of protection and therapeutic measures. Animal testing, in vitro study, and analysis of clinical data, while useful and necessary, are slow, expensive, and often inconclusive. Anatomy and physiolog ...

In Operation Iraqi Freedom (OIF) 61% of soldiers injured in explosion blast events experienced Traumatic Brain Injury (TBI). The current incomplete understanding of TBI mechanisms limits the development of protection and therapeutic measures. Animal testing, in vitro study, and analysis of clinical data, while useful and necessary, are slow, expensive, and often inconclusive. Anatomy and physiolog ...

Sequencing the human genome has uncovered numerous putative novel targets for which 3D structures are not available and which have no known inhibitors. We proposed a system to use computational methodologies to generate 3D molecular models of target proteins, and to use these models to design novel chemical inhibitors. Currently, the system is capable of accurately folding a target's amino acid se ...

CRYOGENIC HELIUM REFRIGERATORS AND LIQUIFIERS CONVENTIONALLYEMPLOY OIL LUBRICATED POSITIVE DISPLACEMENT COMPRESSORS AT THE WARM END AND FREQUENTLY USE PISTON TYPE EXPANSION ENGINES AT THE COLD END. THESE SYSTEMS REQUIRE EXTENSIVE AND VIGILANT MAINTENANCE TO CONTROL CONTAMINATION FROM LUBRICATING OIL AND ITS VOLATILE COMPONENTS MIGRATING TO THE COLD END. HENCE THE NEED FOR LOW MAINTENANCE COMPRESSO ...

THIS PROPOSAL COVERS THE DEVELOPMENT OF A CRYOCOOLER WITH A REFRIGERATION CAPACITY OF 0.75 WATT AT 20 KELVIN. THE CRYOGENIC UNIT WILL HAVE A VOLUME OF LESS THAN 16 CM3, AND CAN PROVIDE COOLING FOR 5 MINUTES AFTER A COOLDOWN PERIOD OF LESS THAN 20 SECONDS. THE CRYOCOOLER USES A NEW FABRICATION TECHNIQUE THAT LEADS TO A HIGH RELATIVE EFFICIENCY WITH A MINIMUM VOLUME.

For the U.S. Navy, Creare is developing a Compact Swaging Machine (CSM) to attach arresting gear Purchase Cable terminals on ship. Our CSM utilizes three innovative features to dramatically reduce the size and weight of the swaging machine to make it usable in a shipboard environment: (1) a high pressure hydraulic system which minimizes the actuator size, (2) an efficient swaging schedule which re ...

The goal of this SBIR project is to develop an innovative, high fidelity computational tool for accurate prediction of aerothermal environment around space vehicles. This tool will be based on the Unified Flow Solver (UFS) developed at CFDRC for hybrid simulations of rarefied, transitional and continuum flows. In this project, UFS will be enhanced to include: radiation transport, non-equilibrium c ...

THIS PROJECT WILL DEVELOP THE APPLICATION OF STATE-OF-THE-ART CHARGE-COUPLED DEVICE (CCD) IMAGE DETECTORSTO THE PROBLEM OF THE AUTOMATIC ANALYSIS OF DNA-SEQUENCING GELS. SUCCESS OF THIS PROJECT WILL RESULT IN COMMERCIALIZATION OF AN INSTRUMENT CAPABLE OF READING, INTERPRETING, AND STORING DNA SEQUENCE INFORMATION DIRECTLY FROM AN AUTORADIOGRAM OF A DNA-SEQUENCING GEL. SUCH AN INSTRUMENT WILL STREN ...

THE DEVELOPMENT OF A LIQUID HELIUM TEMPERATURE CRYOCOOLER ISPLANNED. A REGENERATIVE CRYOCOOLER WILL PROVIDE A 20 K TEMPERATURE SINK OF A JOULE-THOMSON (J-T) STAGE USING HELIUM. AN INNOVATIVE DESIGN FOR THE J-T STAGE HEAT EXCHANGERS WILL ALLOW THE USE OF SIMPLE, HERMETIC COMPRESSORS, WHICH WILL MAKE A PORTABLE, LONG LIFETIME UNIT POSSIBLE. THE STUDY WILL FOCUS ON SYSTEMS HAVING A COOLING POWER OF L ...

High performance metals, ceramics, and hard coatings are used in military applications to enhance the performance of key systems needed by the warfighter. One of the most prevalent operations to remove material, achieve the desired surface finish, or enhance part quality is bulk and finish grinding. For typical cutting speeds, conventional synthetic or oil-based coolants are sufficient to remove ...