Award Data

PROJECT SUMMARYNucleosomesNucsare the repeating units of chromatinmade up of DNA wrapped around a histone octamerChanges in chromatin structurefunction can dramatically impact downstream gene expression and cellular physiologydriving oncogenic reprogramming and cancer progressionThis epigenetic regulation of chromatin is controlled by two major modificationshistone post translational modifications ...

CRYOGENIC HELIUM REFRIGERATORS AND LIQUIFIERS CONVENTIONALLYEMPLOY OIL LUBRICATED POSITIVE DISPLACEMENT COMPRESSORS AT THE WARM END AND FREQUENTLY USE PISTON TYPE EXPANSION ENGINES AT THE COLD END. THESE SYSTEMS REQUIRE EXTENSIVE AND VIGILANT MAINTENANCE TO CONTROL CONTAMINATION FROM LUBRICATING OIL AND ITS VOLATILE COMPONENTS MIGRATING TO THE COLD END. HENCE THE NEED FOR LOW MAINTENANCE COMPRESSO ...

TECHNICAL ABSTRACT: Commercially available unmanned aircraft systems (UASs) are not well designed to meet requirements for many atmospheric measurement applications, including deployment from ships, long endurance, and low cost. Existing multi-rotor systems suffer from limited payload and endurance. Existing fixed wing systems offer improved endurance and payload, but require significant support h ...

For the U.S. Navy, Creare is developing a Compact Swaging Machine (CSM) to attach arresting gear Purchase Cable terminals on ship. Our CSM utilizes three innovative features to dramatically reduce the size and weight of the swaging machine to make it usable in a shipboard environment: (1) a high pressure hydraulic system which minimizes the actuator size, (2) an efficient swaging schedule which re ...

High performance metals, ceramics, and hard coatings are used in military applications to enhance the performance of key systems needed by the warfighter. One of the most prevalent operations to remove material, achieve the desired surface finish, or enhance part quality is bulk and finish grinding. For typical cutting speeds, conventional synthetic or oil-based coolants are sufficient to remove ...

RESEARCH AND DEVELOPMENT WILL BE CARRIED OUT TO PROVIDE PROTOTYPE, ACTIVELY CONTROLLED GAS BEARINGS FOR PRECISION MOVEMENT IN INSTRUMENTS AND MACHINE TOOLS. THIS WILL DRAW UPON PRELIMINARY WORK ON (1) FABRICATION, (2) DYNAMIC ANALYSIS OF THE BEARING AND SUPPORTED MASS, (3) PIEZOELECTRIC VALVING AND PIEZOELECTRIC DISPLACEMENT OF THE BEARING SURFACE, AND (4) THE ADAPTATION OF A MICROPROCESSOR TO SER ...

PROJECT SUMMARY ABSTRACTMillions of children around the globe are afflicted with conditions that can alter neuropsychological developmentincluding human immunodeficiency virusHIVtraumatic brain injuryTBIcerebral malariaand a host of other developmental and acquired diseases and disordersEarly assessment and intervention are critical in overcoming cognitive and developmental deficiencies and are in ...

Arctic Slope Technical Services, Inc. (ASTS) is pleased to propose to continue the development of an additive manufacturing (AM) approach for fabricating bimetallic combustion chambers. Our chamber design, which is applicable to future NASA small launch vehicles, exploits the combined capabilities of selective laser melting (SLM) and magnetic pulse welding (MPW), in order to reduce manufacturing ...

Parent Award: R44CA217587 Clinical Evaluation of the novel, Uni-directional Pd-103 CivaSheet for Lung Cancers CivaTech Oncology’s mission is to provide improved radiation therapy directly to localized tumors. The Company has developed a novel, polymer-encapsulated, membrane-like radiation source that emits radiation on only one side of the device – CivaSheet®. This directional source is compa ...

DESCRIPTION (provided by applicant): The purpose of the proposed project is to develop, implement, and evaluate the use of an Internet-based eLearning multimedia program that will allow foster care social workers, educators, and other youth workers to planone-day real world simulations that would allow adolescent foster youths, ages 13-21, to learn and practice independent living skills. Research ...