Award Data

The main focus of this SBIR Phase II project is to develop a prototype instrument and test cartridges for injectability pre-screening of high concentration protein formulations (HCFs). HCFs are non-Newtonian fluids with shear-thinning behavior and they are formulated to be administered by subcutaneous or muscular injections. The injectability and manufacturability of HCFs depend on the viscosity b ...

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terrible morbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditional vaccines have contributed greatly to public health, they have some limitations especially in the context of operati ...

The proposed low-SWaP PAPR technology improves the convenience, comfort, and protection level for respirators used in low-threat hazardous environments. Creare’s PAPR technology will be applicable to a variety of respiratory protection needs, including emergency escape, laboratory and field work in low-hazard conditions, and some combat and combat support activities. The PAPR will improve user f ...

Through this STTR contract, we propose to evaluate the efficacy of our vaccine, FlowVax Marburg, in nonhuman primates (NHPs). This will be achieved through four Tasks. In Task 1, we will manufacture the vaccine in a quantity sufficient for the animal studies. In Task 2, we will perform MHC genotyping on a representative population of NHPs and, based on results, select a set of MHC-matched NHPs for ...

DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this Phase II effort is to leverage existing public domain resources and commercial tools t ...

Fabrication of stable, nearly 100% internal carrier collection efficiency silicon photodiodes (AXUV diodes) for 1 nm to 600 nm photons was successfully demonstrated by us several years ago. Owing to their excellent characteristics, these devices are being used by NIST as transfer standards in 5 nm to 250 nm range and aboard SOHO, SNOE and TIMED instruments for the EUV solar spectrum studies. Alt ...

A need exists to develop cost effective and reliable submersible cage technology for exposed aquaculture. The team assembled as part of this SBIR incorporates JPS Industries, Great Bay Aquafarms and the University of New Hampshire. In Phase I, a design will be developed based on concepts known to work in the industry. Concepts to be investigated include a cage constructed around HDPE pipe, with ...

SIDE SCAN SONAR HAS DEVELOPED TO THE POINT WHERE IT IS NOW AN ACCEPTED PART OF HYDROGRAPHIC CHARTING PROJECTS, AS WELL AS A BROAD RANGE OF OCEAN SEARCH AND SURVEY APPLICATIONS. ONE LIMITATION ON ITS UTILITY, HOWEVER, IS THE REQUIREMENT TO OPERATE THE SYSTEM AT RELATIVELY LOW SPEEDS (5 KNOTS OR LOR LESS) IN ORDER TO ACQUIRE HIGH-QUALITY DATA. ANY INCREASEIN VESSEL SPEED CAPABILITY WOULD RESULT IN G ...

An innovative optical system with 500X higher ¿tendu and spatial resolution will be designed for CCD-based bistatic lidar. A 100¿ vertical field of view is required to image the laser beam from the ground through the boundary layer, but only a few degrees are required in the horizontal direction. The proposed design is based on dividing the vertical field of view into N sectors, using 1D rasteri ...

The current methodology for testing the penetration resistance of textile materials to various chemical agents has a number of drawbacks, including significant uncertainties in the resulting data, inefficiency and expense, risk to test personnel, and limited range of test conditions. The objective of the proposed work is to apply unique computer models for textiles with accompanying experimental ...