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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Microfluidic DNA Sequencing

    SBC: GNUBIO, INC.            Topic: NHGRI

    DESCRIPTION (provided by applicant): This is a Phase II SBIR proposal to increase the throughput of our DNA sequencing instrument to enable whole genome sequencing with high efficiency and accuracy for a cost of under 1000 per genome. In Phase I, we developed a working sequencing assay, a microfluidic platform and camera system, and analysis methodology that enable genome alignment and variant ca ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  2. Rapid Clinical Surge-Testing for Biothreat Agents

    SBC: FIRST LIGHT BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Following a bioterrorist attack, hundreds of thousands of potential victims may require testing and treatment. The critical need to test large numbers of people for exposure to a biothreat agent may overwhelm the capacity of the clinical and public health infrastructure. The approximately 25,000 sentinel laboratories in the Laboratory Response Network, which co ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  3. RandD- MEDICAL: BIOMEDICAL (BASIC RESEARCH)

    SBC: IMMUNETICS, INC.            Topic: NHLBI

    This project is aimed at the development of an enzyme immunoassay (ELISA) for screening blood for antibodies to Babesia microti. Human babesiosis is a malaria-like illness due to infection of red blood cells by various species of protozoan parasites belonging to the genus Babesia. Most human infections reported in the United States are caused by B. microti which is endemic in parts of the northeas ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  4. Development of an anti-malaria toxin vaccine candidate

    SBC: ANCORA PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Malarial disease represents one of the most pressing medical healthcare issues facing the world today. While limited drug treatment options exist, a vaccine solution is widely considered as one of the most effective therapeutic weapons to combat malaria. Despite years of research, though, malarial vaccine initiatives have yet to produce a viable candidate. One ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  5. ChNKG2D-Targeted Cellular Cancer Therapy: Phase I Clinical Trial

    SBC: CELDARA MEDICAL, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): The global burden of cancer doubled between 1975 and 2000. Cancer became the leading cause of death worldwide in 2010, and is projected to double again by 2020 and to triple by 2030. This horrible disease has touched each of us, and despite enormous investments in prevention and treatment, its impact continues to accelerate. Ideally, any cancer therapy should ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  6. High Field Magnets for MRI Applications

    SBC: Supercon, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The specific aim of the Phase I and Phase II research program will be to design and build an "open", split pair coil, high field (>1 .5T), cryogen-free MRI magnet. The key innovation that will make this goal feasible is the development of an advanced, high performance, round high temperature superconductor capable of operation at 20 Kelvin. Operating at a te ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  7. Spectral imaging for automated malignant blast counting

    SBC: CAMBRIDGE RESEARCH AND INSTRUMENTATION            Topic: N/A

    DESCRIPTION (provided by applicant): We propose to extend our successful development of an agile spectral light source for light microscopy, funded through the NCI-IMAT initiative, into FDA trials. The SpectraLamp(tm) device enables the automated and quantitative analysis of double-immunostained samples in brightfield (non-fluorescence-based) microscopy, with particular utility for hematopatho ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  8. A Rapid Point-of-care Diagnostic for C. trachomatis STDs

    SBC: NetBio, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): Improved diagnosis of Chlamydia trachomatis (Ct) infections represents a critical unmet medical need. Ct is the most common cause of bacterial sexually transmitted diseases (STD) worldwide, and the Centers for Disease Control and Prevention estimate that there are 2.8 million US cases annually. Currently, 40% of women with untreated infection will develop pelvi ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  9. Novel Methylenecyclopropane Analogues as Anti-Human Herpesvirus 6 and 8 Agents

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): The human herpesviridae family contains eight members divided into three subfamilies, designated alpha, beta and gamma. The alpha herpes viruses include herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2) and varicella zoster virus (VZV). The beta herpes viruses include human cytomegalovirus (HCMV), two variants of human herpes virus 6 (HHV ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  10. Lab-on-a-Chip for Multiplexed Newborn Screening of Lysosomal Storage Disorders

    SBC: ADVANCED LIQUID LOGIC            Topic: NICHD

    DESCRIPTION (provided by applicant): Newborn screening is currently performed by collecting dried bloodspots from infants and then sending them to a lab for analysis. It is primarily performed to detect disorders which lead to severe physical and mental disabilities. There is an increasing necessity to screen for a number of lysosomal storage disorders for which therapies are becoming available. T ...

    SBIR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
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