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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Organismal Radioprotection Through Pharmacological Quiescence

    SBC: G1 THERAPEUTICS, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Syndrome (ARS), including a lethal myelosuppression due to the sensitivity of proliferating hematopoietic stem/progenitor cells (HSPCs) to ionizing radiation (IR). No effective therapy exists to mitigate the hematologictoxicities of TBI. Herein G-Zero Therapeutics seeks to further the proprietary development of small molecule inhibitors of cyclin-dependent kina ...

    SBIR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  2. Photoacoustic CT for Preclinical Molecular Imaging

    SBC: OPTOSONICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term objective of this collaborative research project is to commercialize a prototype photoacoustic computed-tomography (PCT) scanner for conducting preclinical molecular imaging. This scanner has been developed by OptoSonics with funding from a Fast Track SBIR grant from the National Cancer Institute (R44-CA-102891) and additional private funding fro ...

    SBIR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
  3. Validation and commercialization of a/LCI for detection of esophageal neoplasia

    SBC: Oncoscope, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): The objective of this research is to commercialize a device (the Oncoscope Panocyte system) used to guide biopsy selection in patients with Barrett's esophagus (BE) during standard endoscopy surveillance for early- stage esophageal cancer. Barrett's esophagus most often develops in patients with chronic acid reflux and is the strongest risk factor fo ...

    SBIR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  4. Regulatory Advancement of HXe as a Diagnostic MRI Contrast Agent

    SBC: XEMED LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): New therapies are in development for COPD (endobronchial valves/stents/glue) and asthma (endobronchial thermal ablation). Hyperpolarized xenon-129 (HXe) MRI, a noninvasive method to assess regional lung structure and function, may prove critical in the guidance of these regional treatments. In our prior work we developed an innovative approach to xenon polariza ...

    SBIR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  5. Preclinical Development of a Novel and Powerful Immunotherapeutic

    SBC: IMMURX LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): ImmuRx is developing a novel and potent immunotherapeutic product to stimulate the immune system. This will significantly increase the efficacy of existing and new therapeutic vaccines for the treatment of cancers suchas melanoma, lymphoma and lung cancer and for chronic infectious diseases such as Hepatitis C. The barrier to the induction of protective, thera ...

    SBIR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  6. Pediatric Spectral Domain Optical Coherence Tomography

    SBC: BIOPTIGEN, INC.            Topic: NEI

    DESCRIPTION (provided by applicant): Acquiring diagnostic images of the retina in children is necessary to the prevention and treatment of pediatric eye disease, but it is often difficult due to the large range of eye shapes and sizes from preemies to older children and the inability of most children within this range to fixate. Fundus photography only provides a two- dimensional surface picture o ...

    SBIR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  7. Definitive Studies For Use Of Galantamine As A Pre-Treatment Countermeasure Again

    SBC: Countervail Corporation            Topic: NINDS

    DESCRIPTION provided by applicant Fast Track SBIR Phase I and Phase II Exposure to centrally acting military nerve agents and organophosphorus OP pesticides are known to cause death and neurological damage Coupland Karalliedee Buckley Improved countermeasures to intoxication from these compounds are needed In numerous studies Albuquerque conducted at the University of Maryland School of Medicine U ...

    SBIR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  8. Self Assembling High Affinity Peptides for Point of Care Drug-Device Combinations

    SBC: AFFINERGY, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Infection surrounding metal implants is a common and sometimes devastating cause of implant failure in a number of fields including oral, craniomaxillofacial (CMF), orthopedic, and cardiovascular surgery. These infections, which arise from the establishment of biofilms on device surfaces, not only necessitate new surgeries but in themselves present a significan ...

    SBIR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
  9. Commercialization of Human Mesothelial Cells for Research

    SBC: Zen-Bio, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Mesothelial cells have been found to be pivotal in tumor metastasis, peritoneal dialysis, and inflammatory response. These cells are specialized epithelial cells that line the peritoneal, pericardial, and pleural cavities and internal organs presenting a barrier to invading organisms and physical damage. Ovarian tumor attachments occur through cancer cells bind ...

    SBIR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
  10. Point of Care Adult Stem Cell Isolation

    SBC: AFFINERGY, LLC            Topic: NIAMS

    DESCRIPTION (provided by applicant): Approximately 500,000 bone-grafting procedures are performed each year in the United States.5 Autologous iliac crest bone graft continues to be the gold standard, because it provides essential elements for bone formation: progenitor cells, an osteoconductive matrix, and osteoinductive molecules. However, iliac crest harvest is associated with a significant numb ...

    SBIR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
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