Award Data

Abstract: Femoroacetabular impingement or FAI is a commonly diagnosed condition affecting a younger patient population than the general osteoarthritis (OA) population. Untreated, FAI invariably leads to OA and, ultimately, total hip arthroplasty (THA). The fact that most FAI diagnoses are made in patients under the age of 40, with many in their late teens and twenties, makes FAI all the more clini ...

Project Summary Autism Spectrum Disorder (ASD) is a broad diagnosis for a disorder characterized by symptoms affecting repetitive behavior, social communication, and cognitive ability. 1 in 68 children in the US is affected with ASD (Centers for Disease Control and Prevention, 2017) and the likelihood that a child will be affected with ASD is 10 times higher if they have a sibling with ASD. Tradit ...

PROJECT SUMMARY (ABSTRACT) Spinal cord injury (SCI) affects an estimated 285,000 Americans. Damage to nerves in the spinal cord can result in a loss of voluntary control over bladder and bowel function that often produces both incontinence and retention of urine and stools in the same patient. The standard of care for urine retention is bladder catheterization to void urine, which may produce urin ...

PROJECT SUMMARY End Stage Renal Disease (ESRD) affects more 750,000 individuals in the United States alone. Hemodialysis (HD) is a life-sustaining therapy for patients suffering from renal failure that requires blood to be withdrawn and cycled through a dialysis machine. This process requires repeated needle punctures and the consequent needle access to a surgically created vascular shunt. These s ...

DESCRIPTION (provided by applicant): The long-term objective of this collaborative research project is to commercialize a prototype photoacoustic computed-tomography (PCT) scanner for conducting preclinical molecular imaging. This scanner has been developed by OptoSonics with funding from a Fast Track SBIR grant from the National Cancer Institute (R44-CA-102891) and additional private funding fro ...

ABSTRACT Digital Microfluidics – Minimizing Blood Volume for Pediatric Coagulation Screening (SBIR Phase IIB) Newborns and young children undergoing cardiac surgery are at significantly increased risk for a major thrombosis event, and comprehensive hypercoagulability screening is indicated in children who have suffered a major thrombotic or thromboembolic event, or who have a family history of t ...

Miya Model™ Simulator: Phase II B Abstract OB/GYN Residents must develop numerous skills including pelvic exams, childbirth, open surgery, laparoscopic surgery, and vaginal surgery. Studies demonstrate that OB/GYN Residents lack training in vaginal surgical techniques, including Vaginal Hysterectomy (VH), the desired hysterectomy technique recommended by The American College of Obstetricians and ...

PROJECT SUMMARYChromatin structure and gene expression are controlled by histone post-translational modifications (PTMs) on nucleosomes, the basic repeating unit of chromatin. Chromatin decondensation is controlled in part by the PAD4-dependent conversion of arginine to citrulline on histones (i.e. citrullination). Significantly, PAD4 activation in neutrophils initiates a cell death program distin ...

PROJECT SUMMARY The filoviruses (family Filoviridae), comprising five ebolaviruses, a cuevavirus, and two Marburg viruses, are negative-strand RNA viruses that cause severe hemorrhagic fever with up to 90% human case fatality rate. The 2014–2016 epidemic in Western Africa, caused by the Zaire ebolavirus (EBOV) species demonstrated the potential for these viruses to cause dire health emergencies ...

Summary: This Phase IIb grant application describes a plan for demonstrating significant improvement of identifying ASD subjects at a very young age and facilitating diagnostic assessments for autism earlier via a proven telehealth service. The plan includes partnering with a private company (CHADIS) that has a substantial client base of referring pediatricians already using their technology to sc ...