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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Cartilage Regeneration with Tunable Inflammation Resistance

    SBC: Cytex Therapeutics, Inc.            Topic: R

    Abstract: Femoroacetabular impingement or FAI is a commonly diagnosed condition affecting a younger patient population than the general osteoarthritis (OA) population. Untreated, FAI invariably leads to OA and, ultimately, total hip arthroplasty (THA). The fact that most FAI diagnoses are made in patients under the age of 40, with many in their late teens and twenties, makes FAI all the more clini ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  2. Objective, MRI biomarkers for pre-symptomatic detection of autism spectrum disorder at 6 months old: commercial software development and optimization

    SBC: PrimeNeuro, Inc.            Topic: 103

    Project Summary Autism Spectrum Disorder (ASD) is a broad diagnosis for a disorder characterized by symptoms affecting repetitive behavior, social communication, and cognitive ability. 1 in 68 children in the US is affected with ASD (Centers for Disease Control and Prevention, 2017) and the likelihood that a child will be affected with ASD is 10 times higher if they have a sibling with ASD. Tradit ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Preclinical characterization of a novel neuropeptide for inducing "on-demand" voiding

    SBC: Dignify Therapeutics LLC            Topic: 105

    PROJECT SUMMARY (ABSTRACT) Spinal cord injury (SCI) affects an estimated 285,000 Americans. Damage to nerves in the spinal cord can result in a loss of voluntary control over bladder and bowel function that often produces both incontinence and retention of urine and stools in the same patient. The standard of care for urine retention is bladder catheterization to void urine, which may produce urin ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  4. Organismal Radioprotection Through Pharmacological Quiescence

    SBC: G1 THERAPEUTICS, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Syndrome (ARS), including a lethal myelosuppression due to the sensitivity of proliferating hematopoietic stem/progenitor cells (HSPCs) to ionizing radiation (IR). No effective therapy exists to mitigate the hematologictoxicities of TBI. Herein G-Zero Therapeutics seeks to further the proprietary development of small molecule inhibitors of cyclin-dependent kina ...

    SBIR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  5. A Bullet Proof vascular graft to prevent dialysis access cannulation injury

    SBC: Innavasc Medical, Inc.            Topic: 400

    PROJECT SUMMARY End Stage Renal Disease (ESRD) affects more 750,000 individuals in the United States alone. Hemodialysis (HD) is a life-sustaining therapy for patients suffering from renal failure that requires blood to be withdrawn and cycled through a dialysis machine. This process requires repeated needle punctures and the consequent needle access to a surgically created vascular shunt. These s ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  6. Validation and commercialization of a/LCI for detection of esophageal neoplasia

    SBC: Oncoscope, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): The objective of this research is to commercialize a device (the Oncoscope Panocyte system) used to guide biopsy selection in patients with Barrett's esophagus (BE) during standard endoscopy surveillance for early- stage esophageal cancer. Barrett's esophagus most often develops in patients with chronic acid reflux and is the strongest risk factor fo ...

    SBIR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  7. Regulatory Advancement of HXe as a Diagnostic MRI Contrast Agent

    SBC: XEMED LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): New therapies are in development for COPD (endobronchial valves/stents/glue) and asthma (endobronchial thermal ablation). Hyperpolarized xenon-129 (HXe) MRI, a noninvasive method to assess regional lung structure and function, may prove critical in the guidance of these regional treatments. In our prior work we developed an innovative approach to xenon polariza ...

    SBIR Phase II 2011 Department of Health and Human ServicesNational Institutes of Health
  8. Digital Microfluidics- Minimizing Blood Volume for Pediatric Coagulation Screening

    SBC: BAEBIES, INC.            Topic: NHLBI

    ABSTRACT Digital Microfluidics – Minimizing Blood Volume for Pediatric Coagulation Screening (SBIR Phase IIB) Newborns and young children undergoing cardiac surgery are at significantly increased risk for a major thrombosis event, and comprehensive hypercoagulability screening is indicated in children who have suffered a major thrombotic or thromboembolic event, or who have a family history of t ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  9. Effect of Validated Skills Simulation with the Miya Model on Operating Room Performance of Vaginal Hysterectomy

    SBC: MIYAZAKI ENTERPRISES LLC            Topic: NICHD

    Miya Model™ Simulator: Phase II B Abstract OB/GYN Residents must develop numerous skills including pelvic exams, childbirth, open surgery, laparoscopic surgery, and vaginal surgery. Studies demonstrate that OB/GYN Residents lack training in vaginal surgical techniques, including Vaginal Hysterectomy (VH), the desired hysterectomy technique recommended by The American College of Obstetricians and ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  10. Rapid quantification of nuclear citrullination in human neutrophils

    SBC: Epicypher, Inc.            Topic: NIAID

    PROJECT SUMMARYChromatin structure and gene expression are controlled by histone post-translational modifications (PTMs) on nucleosomes, the basic repeating unit of chromatin. Chromatin decondensation is controlled in part by the PAD4-dependent conversion of arginine to citrulline on histones (i.e. citrullination). Significantly, PAD4 activation in neutrophils initiates a cell death program distin ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
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