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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Clinical Development of a Therapeutic Agent for COPD

    SBC: BIOMARCK PHARMACEUTICALS, LTD            Topic: NHLBI

    DESCRIPTION provided by applicant Hypersecretion of mucus into the respiratory airways is a major contributing factor in several lung diseases including chronic pulmonary disease COPD asthma cystic fibrosis allergic rhinitis and bronchiectasis Despite the obvious medical importance there presently are no effective therapies to control excess mucus secretion in these diseases and very ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  2. Safe and effective anti CD154 antibodies for therapeutic intervention

    SBC: Immunext, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant In both animal proof of concept studies and preliminary clinical trials there is ample data demonstrating the potential therapeutic benefits o CD blockade for treatment of GVHD organ transplantation and autoimmune diseases However development of CD as a therapeutic has been impeded by antibody toxicity observed in early clinical trials GVHD is a ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  3. Novel Manufacturing Processes for Tissue Engineered Vascular Grafts

    SBC: HUMACYTE, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant This Phase IIB SBIR application is responsive to NHLBI RFA HL andquot NHLBI SBIR Phase IIB Bridge Awards to Accelerate the Commercialization of Technologies for Heart Lung Blood and Sleep Disorders and Diseases R andquot This RFA solicits work on andquot basic applied and clinical research on all product and service development related to the ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  4. Single-session bronchial thermoplasty for severe asthmatics guided by HXe MRI

    SBC: XEMED LLC            Topic: NHLBI

    DESCRIPTION provided by applicant Roughly one million Americans with inadequately controlled severe persistent asthma have a particularly high risk of exacerbations hospitalizations and death and account for a per patient health care burden exceeding $ annually Bronchial thermoplasty BT applies radiofrequency heating to airway smooth muscle reducing its thickness and hyper reactivity This novel mi ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  5. Improved diagnostic and monitoring assays for thyroid cancer

    SBC: Soymeds Inc            Topic: NCI

    DESCRIPTION provided by applicant Thyroid cancer is the most common type of endocrine malignancy New thyroid cancers patients are identified daily and most patients live for decades following diagnosis Thyroglobulin TG levels in the sera or in fine needle biopsies of thyroid cancer patients are routinely quantified using various agency approved e g FDA immunoassays for diagnostic and p ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  6. Model-Based Design of Test Systems for Chemical Protective Clothing

    SBC: CREARE LLC            Topic: CBD02202

    The current methodology for testing the penetration resistance of textile materials to various chemical agents has a number of drawbacks, including significant uncertainties in the resulting data, inefficiency and expense, risk to test personnel, and limited range of test conditions. The objective of the proposed work is to apply unique computer models for textiles with accompanying experimental ...

    SBIR Phase II 2005 Department of DefenseOffice for Chemical and Biological Defense
  7. Hermetic Textile Closure Hardware System

    SBC: SIGMA K CORP            Topic: CBD04110

    Effective collective protection fabrics must have a reliable closure system. During our Phase I Work Plan, Sigma-K began developing a Hermetic Textile Closure Hardware (HATCH) system. The HATCH combines both a magnetic and geometric self locking mechanism that will provide a hermetic seal when closed. Our current Phase I successes include developing self closing samples that can provide a hermetic ...

    SBIR Phase II 2005 Department of DefenseOffice for Chemical and Biological Defense
  8. Analysis Tools for Detection and Diagnosis of Biological Threats

    SBC: ALPHA-GAMMA TECHNOLOGIES, INC.            Topic: CBD04113

    DNA microarray technology, in combination with statistical and predictive modeling tools, could be used to evaluate thousands of genes against distinct gene expression patterns induced by chemical/biological agents to provide early identification and speed therapeutic intervention. The overall objective of this Phase II effort is to leverage existing public domain resources and commercial tools t ...

    SBIR Phase II 2005 Department of DefenseOffice for Chemical and Biological Defense
  9. An Aerosol Device for Measles Vaccination (B)

    SBC: CREARE LLC            Topic: NA

    N/A

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  10. MINDFULNESS BASED SUBSTANCE ABUSE PREVENTION PROGRAM FOR ADOLESCENTS WITH FASD

    SBC: Innovation Research And Training, Inc.            Topic: NICHD

    Adolescents with Fetal Alcohol Spectrum Disorder FASD are at risk for substance use and abuse Given the dearth of interventions designed specifically for adolescents with FASD there exists a need for evidence based preventive intervention programs for this population Thus the goal of the proposed Phase II application is to complete the product development and evaluate the effectiveness of t ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
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