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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Validation of a Negative Regulator as a Novel Therapy for Autoimmune Disease

    SBC: Immunext, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Systemic lupus erythematosus SLE is a devastating autoimmune disease that most commonly affects women in their child bearing years SLE attacks multiple organ systems but renal and neurologic involvement are the usual harbingers of poor outcome Despite effective albeit toxic immunosuppressive therapy only of patients with these serious manifestations ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Novel therapeutics for fatty liver disease and type-II diabetes

    SBC: SOUTHEAST TECH INVENTURES            Topic: 200

    DESCRIPTION provided by applicant Western lifestyle and diet have spurred the growth of numerous obesity related disorders in the US including metabolic syndrome and type diabetes to epidemic proportions However less well known is the rising epidemic of non alcoholic fatty liver disease NAFLD NAFLD ranges from mild hepatosteatosis to severe fibrosis or cirrhosis and is initially charac ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a drug discovery platform for human islets

    SBC: Zen-Bio, Inc.            Topic: 200

    DESCRIPTION provided by applicant Diabetes and diabetes related co morbidities are at epidemic proportions and an enormous burden to our healthcare system Although there has been significant progress in defining the causative factors and molecular mechanisms involved in both type and type diabetes it remains an overwhelming challenge to identify efficacious therapeutic modalities Novel a ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Anti-biofilm agents for the treatment of pulmonary infection in cystic fibrosis p

    SBC: AGILE SCIENCES, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The leading cause of mortality in patients with cystic fibrosis CF is pulmonary failure from lung infections and the predominant organism isolated from these infections is the bacterium Pseudomonas aeruginosa Lung infections of CF patients persist over the lifetime of the patients and are impossible to eradicate due to the ability of bacteria to form biofi ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Selective Fyn kinase inhibitors for treatment of metabolic disease

    SBC: Zen-Bio, Inc.            Topic: 200

    DESCRIPTION provided by applicant Metabolic diseases such as type diabetes T D obesity and their related co morbidities have reached epidemic proportions worldwide While progress continues to be made into the molecular mechanisms involved in both obesity and T D the identification and development of safe efficacious therapeutic modalities is significantly limited There is an urgent nee ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Gene Expression Signatures to Predict Treatment Response in Systemic Sclerosis

    SBC: CELDARA MEDICAL, LLC            Topic: NIAMS

    DESCRIPTION provided by applicant Today systemic sclerosis SSc clinical trials generally include all subsets some may benefit others do not confounding measures of efficacy Because each expression subset has a different underlying deregulated molecular pathway no single drug is expected to benefit all patients i e rational patient selection is required to facilitate drug development F ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  7. A Quantitative Optical Sensor to Monitor Tumor Vascular Physiology

    SBC: Zenalux Biomedical, Inc.            Topic: 102

    DESCRIPTION provided by applicant In there were new cases of head and neck cancers HNC in the United States Early detection of new and locally recurrent cancers is clinically important to reduce not only cancer related mortality but also treatment associated morbidity as it impacts multiple organ functions including respiration olfaction hearing eating swallowing and speak ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Wireless and Noise Attenuating Headset for Automated Hearing Screening

    SBC: CREARE LLC            Topic: NIDCD

    DESCRIPTION provided by applicant Hearing loss is a leading public health concern with about of American adults reporting some degree of impairment Of those fewer than seek help for their condition for a variety of reasons To address this issue the National Institue of Deafness and Other Communication Disorders NIDCD is seeking solutions to improve hearing healthcare access and l ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  9. TheraSense Dynamic Support Surface for Pressure Ulcers

    SBC: Simbex LLC            Topic: 600

    DESCRIPTION provided by applicant The Principal Objective of this Fast Track SBIR project is to develop and validate a cost effective commercial product TheraSenseandquot a highly innovative active support surface bed system for the treatment and prevention of serious decubitus ulcers commonly known as bed sores or pressure ulcers Current advanced bed systems for both institutional and ho ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Integration of Genomic Biomarkers with the devTOX Human Embryonic Stem Cells Scre

    SBC: Integrated Laboratory Systems, LLC            Topic: NIEHS

    DESCRIPTION provided by applicant In utero exposure to environmental chemicals or drugs accounts for approximately of all birth defects and can have an impact in adult life by disrupting the epigenetic developmental programs that are activated later in life e g puberty aging The currently accepted regulatory test for identifying potential teratogens involves the use of thousands of ani ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
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