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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. New generation of catheters for treatment of atrial fibrillation

    SBC: NOCTURNAL PRODUCT DEVELOPMENT, LLC            Topic: NHLBI

    DESCRIPTION provided by applicant Atrial fibrillation AF remains the most commonly occurring cardiac arrhythmia It is associated with a lower quality of life and a higher rate of morbidity andamp mortality primarily due to poor hemodynamics and often stroke One of the main options to treat atrial fibrillation is to ablate abnormal sources of electrical activity using percutaneous radiofrequ ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Video Rate optical verification tool for radiotherapy treatment plans

    SBC: DoseOptics LLC            Topic: 101

    Abstract For the first time it is possible to directly visualize a radiation beam hitting a patientandapos s tissue or high resolution imaging of radiation delivery in water tank phantoms using Cherenkov emission imaging This allows the opportunity to do pre treatment verification at high resolution with real time video of a test phantom prior to delivery to the patient Radiotherapy has a di ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Safe and effective anti CD antibodies for therapeutic intervention

    SBC: Immunext, Inc.            Topic: R

    Abstract CD CD L is a key target for immunomodulation due to its central role in controlling the activation of the immune system This well studied immune switch has been the focus of extensive drug development for over two decades The validation of this drug target consists of reproducible and robust data using rodent and NHP models of chronic inflammation autoimmune disease and organ ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Internally Calibrated Chromatin Immunoprecipitation Using Barcoded Nucleosomes

    SBC: Epicypher, Inc.            Topic: 172

    DESCRIPTION provided by applicant Chromatin immunoprecipitation ChIP is one of the core methods in the study of epigenetic regulation of gene expression Analytical methods such as qPCR microarray and next generation sequencing NGS have increased throughput but not the reliability of ChIP datasets Using state of the art reagents ChIP is at best semi quantitative and at worst unreprese ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  5. The CellRaft AIR System Workflow Automation for Stem Cell Isolation and Recovery

    SBC: Cell Microsystems, Inc.            Topic: 200

    DESCRIPTION provided by applicant Stem cell research is an emerging field with the promise of creating dramatic new approaches for disease treatment and drug discovery The research and regenerative medicine market space for stem cells is one of the most dynamic areas in the life science industry today Globally the stem cell market is growing at a CAGR of and will reach an approximate ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a treatment for voiding dysfunction in spinal cord injured patients

    SBC: Dignify Therapeutics LLC            Topic: NICHD

    DESCRIPTION provided by applicant Loss of voluntary control over bladder and bowel function as a result of spinal cord injury SCI has profound impact on the mental and physical health status and quality of life of individuals It is estimated that people in the USA have SCI https www nscisc uab edu PublicDocuments fact figures docs pdf Urinary retention as a result of SCI is irr ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Development and validation of a human brown adipocyte system

    SBC: Zen-Bio, Inc.            Topic: 200

    Project Summary The activation and recruitment of brown adipose tissue has become an exciting target in the fight against obesity and its related metabolic diseases Brown adipose tissue differs from white adipose tissue in its critical ability to burn energy as heat through UCP driven adaptive thermogenesis Expression of mitochondrial UCP uncouples oxidative phosphorylation resulting in acc ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Development and Validation of the Miya Model A Simulator Designed to Train Vaginal Surgery Techniques

    SBC: MIYAZAKI ENTERPRISES, LLC            Topic: NICHD

    Miya Model Simulator Phase II Abstract OB GYN Residents must develop numerous skills including pelvic exams child birth open surgery laparoscopic surgery and vaginal surgery Studies demonstrate that OB GYN Residents lack training in vaginal surgical techniques including Vaginal Hysterectomy VH Vaginal Hysterectomy is the desired technique recommended by The American College of Obstetric ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  9. New Class of Bright Sharp Tunable Near Infrared Fluorophores for Flow Cytometry

    SBC: Nirvana Sciences, Inc.            Topic: R

    DESCRIPTION provided by applicant Polychromatic flow cytometry FC is one of the most powerful analytical techniques routinely used by both basic research and clinical diagnostics laboratories for the immunological categorization of cells Dyes used for FC typically exhibit broad fluorescent emission bands with full width at half maximum fwhm values of nm This limits the maximum numbe ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Multiplex platform for point of care newborn screening of hyperbilirubinemia

    SBC: Baebies, Inc.            Topic: NICHD

    ABSTRACT Multiplex Platform for Point of Care Newborn Screening of Hyperbilirubinemia PAR Neonatal jaundice is a frequent condition which when unmonitored or untreated can lead to severe neonatal hyperbilirubinemia HBR and associated morbidities Following guidelines set by the American Academy of Pediatrics most babies in the U S are screened for hyperbilirubinemia by testing bili ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
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