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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Predicting DILI liability by transcription factor profiling

    SBC: ATTAGENE, INC.            Topic: 400

    PROJECT SUMMARYDrug induced liver injuryDILIis the main reason for drug attrition during development and a leading cause of post market drug withdrawalHerewe propose a systems biology approach to detect drug candidates with DILI liabilities at early stages of developmentThis approach is based on the assessment of drug induced perturbations of multiple signal transduction pathways in hepatocytic ce ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Targeting the checkpoint regulator VISTA for treatment of inflammatory disease

    SBC: Immunext, Inc.            Topic: R

    ImmuNext has identified and developed a putative lead anti VISTA monoclonal antibodymAbthat we aim to bring to the clinic for the treatment of human autoimmune diseaseVISTA is a member of the highly successful negative checkpoint regulatorNCRfamily of drug targetswhose members have demonstrated proven efficacy in inducing long term remissions in human cancersWe contend that antibodies that suppres ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  3. A Phase III Trial to Validate HP 129Xe MRI as a Functional Pulmonary Biomarker in Pediatric Lung Disease

    SBC: POLAREAN, INC.            Topic: NHLBI

    PROJECT SUMMARYABSTRACT Chronic respiratory diseasessuch as COPDasthmaand cystic fibrosisCFare therd leading cause of death in the USwith costs exceeding $B yearA major obstacle to evaluate therapies for these diseases is that currently available tools to assess lung function are either insensitive to early disease or unsuitable for longitudinal useThough ubiquitouspulmonary function testing via s ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a mobile and automated platform for multiplexed multi-modality imaging

    SBC: Sonovol, Inc.            Topic: 102

    Abstract Bioluminescence imagingBLIsystems are installed in thousands of facilities and labsand with their straightforward and low cost workflow for longitudinal studiesare the most commonly used preclinical modality for assessing tumor models in rodentsThere currently is no high throughput and low cost system enabling BLI images to be combined with anatomical images of soft tissue to confirm tumo ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Novel technologies for detection of podocytes from preeclamptic patients

    SBC: AFFINERGY, LLC            Topic: NICHD

    Preeclampsia is a complication of pregnancy characterized by elevated blood pressureproteinuriaand endothelial dysfunction involving multiple organ systemsWorldwidepreeclampsia is the largest cause of fetal and maternal morbidity and mortalityand accounts for nearlyof maternal deaths in the United States alone each yearCurrentlythere is no approved diagnostic test to predict which patients will de ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Open Source System for Audio Processing

    SBC: CREARE LLC            Topic: NIDCD

    This proposal responds to RFA–DC-16-002, in which the NIDCD is seeking to support the development of acoustic signal processing tools that have the potential to accelerate research studies and to facilitate the translation of novel algorithms for hearing aids. Approximately 15% of American adults report some degree of hearing trouble, and 12.7% of Americans aged 12 and over experience bilateral ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  7. The Impact Integrated Data System for Quality and Outcomes Tracking of Prevention Programs

    SBC: 3-C Institute for Social Development, Inc.            Topic: 104

    Abstract There has been substantial progress in developing evidence based prevention programsEBPPsfor preventing risky behaviors and promoting positive mental health outcomes for youthUnfortunatelyEBPP adoptionquality implementationlong term sustainabilityand scalability in real world service settings continues to lag far behindjeopardizing the ability to achieve the intended broad scale public im ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A crosslinked cartilage-derived matrix for cartilage tissue engineering

    SBC: Cytex Therapeutics, Inc.            Topic: NIAMS

    Abstract OsteoarthritisOAremains a significant source of significant pain and disabilityaffecting overmillion adults with an economic burden of over $billion per year to the USJoint replacement is a well established procedurebut its finite life span makes this treatment unacceptable for younger or more active individualswho often require additional revision surgeries as they ageBoth complicated re ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Functional Tissue Engineering for Cartilage Repair

    SBC: Cytex Therapeutics, Inc.            Topic: NIA

    Abstract It is estimated that only aboutof young patients suffering from!activity limiting hip osteoarthritisOAchoose to undergo traditional hip replacement surgeryThis low percentage is attributed to the shortened projected lifetime of hip implants for active patients and the subsequent need for revision surgeries that are plagued with higher complication rates and overall decreased effectiveness ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Signal Processing for Layered Sensing

    SBC: Vadum, Inc.            Topic: CBD152006

    Vadum will develop Chemical, Heterogeneous sensor fusion Incident awareness Module (CHIME)asoftware module that will ingest data from a large number of asynchronous, heterogeneous and multi-tiered sensors to automate the process of estimating the source attributes of a chemical or biological release. CHIME generates estimates from a continuous stream of raw sensor data with successive estimates al ...

    SBIR Phase II 2017 Department of DefenseOffice for Chemical and Biological Defense
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